空肠弯曲杆菌是导致细菌性腹泻的主要病原菌。随着抗生素在治疗和预防方面的大量使用，空肠弯曲杆菌耐药性的问题日益严峻。利用乳酸菌来预防或辅助治疗空肠弯曲杆菌感染是最好的替代途径。本课题在前期体外筛出具有抗空肠弯曲杆菌活性的乳酸菌的研究基础上，拟利用细胞模型和动物模型来研究植物乳杆菌及其代谢产物对空肠弯曲杆菌感染细胞及肠道定植过程的影响；从免疫调控、信号转导等方面入手，研究植物乳杆菌及其代谢产物在干预空肠弯曲杆菌导致宿主肠道损伤中所发挥的作用；分析植物乳杆菌干预空肠弯曲杆菌感染后肠道微生态状况，从分子水平上认识乳酸菌干预空肠弯曲杆菌感染的作用机理。研究结果有助于进一步认识乳酸菌在拮抗空肠弯曲杆菌感染中发挥有益作用的生理基础，为功能性益生乳酸菌的开发奠定理论依据和提供理论指导。

Campylobacter jejuni is known human pathogens that are capable of causing disease ranging from diarrhea to serious neurological disorders. Antibiotic is normally considered for treatment of Campylobacter jejuni.However,the increasing concern about the spreading of antibiotic resistance in humans has determined the elimination of antibiotics as growth promoters in livestock. An alternative and effective approach to antibiotic administration to livestock is the use of probiotics, which can help to improve gut microbial balance and therefore the natural defence of the animal against C. jejuni. Based on the lactic acid bacteria with antagonistic activities against C. jejuni that have been screened in vitro, the project is designed to discover the effects of lactic acid bacteria and their metabolin on the infection process of C. jejuni in both cell and animal models; Investigate their function of intervention on damage of host cells caused by C. jejuni from aspects of immune regulation, signal transduction; Analyze the micro-ecological status of the digestive system of animal models in which lactic acid bacteria interfere with C. jejuni so as to understand the intervention mechanisms of the antagonistic activtities against C. jejuni at the molecular and cell level. The combined results will help to recognise he benifits of lactic acid bacteria in antagonizing infection of C. jejuni, thus to provide theoretical guidance of developing functional lactic acid bacteria.