前期的研究发现易感基因UGRP1在90%的桥本甲状腺炎和25%的GD甲状腺滤泡细胞中表达，而在非自身免疫性甲状腺疾病（AITD）中不表达。与UGRP1阴性GD相比，UGRP1阳性GD甲状腺组织浸润的淋巴细胞较多，TPOAb阳性率高。UGRP1阳性甲状腺滤泡，其Fas和MHC分子表达明显增高。本项目在这些发现基础上，进一步明确：1. UGRP1阳性和阴性GD甲状腺组织中，浸润的淋巴单核细胞种类及分泌的细胞因子是否不同，它们是否是不同的甲亢类型；2. 明确AITD甲状腺滤泡细胞UGRP1、Fas和MHC共表达的分子机制；3. 明确UGRP1阳性和阴性甲状腺滤泡细胞基因表达谱及细胞功能差异，是否存在UGRP1阳性和阴性GD的血清学和组织学鉴别诊断的分子标志；4. UGRP1阳性甲状腺滤泡细胞，是否在抗原递呈及激活T淋巴细胞上与阴性细胞有明显差异，明确UGRP1参与AITD发生的分子机制。

Previous studies have found that UGRP1 is expressed in 90% of Hashimoto's thyroiditis and 25% of GD thyroid follicle cells, but not in non-autoimmune thyroid disease (AITD). Compared with UGRP1 negative GD, lymphocytes infiltration and TPOAb positive rate as well as the expression of Fas and MHC molecules in UGRP1 positive GD thyroid tissue are markedly increased. Based on these findings, this project is aimed to clarify: 1.If the types of lymphoid monocyte infiltrated and cytokines secreted are different in UGRP1 positive and negative GD thyroid tissue, and if they are different types of hyperthyroidism; 2.The molecular mechanism mediated the co-expression of UGRP1, Fas and MHC in AITD thyroid follicular cells; 3.The difference of gene expression and cell function in UGRP1 positive and negative thyroid follicle cell, and if there are molecule markers contributing to serological and histological diagnosis of UGRP1 positive and negative GD; 4.Whether there are differences in antigen presentation and T lymphocytes activation in UGRP1 positive thyroid follicle cells and negative cells, and if UGRP1 is involved in the mechanism of AITD occurrence.