对虾是我国水产养殖的主要种类，2015年我国养殖对虾总产量约190万吨，其中凡纳滨对虾养殖产量所占比例超过85%。白斑综合症病毒（White spot syndrome virus, WSSV）是养殖对虾中出现的主要传染性病毒之一，由其引发的白斑综合症（White spot syndrome, WSS）是影响我国凡纳滨对虾养殖业发展的最主要瓶颈因素。本研究以凡纳滨对虾为研究对象，拟通过进行（1）GSK3β对NFκB的调控作用、（2）GSK3β对IκB的调控作用、（3）NFκB对GSK3β的调控作用、（4）GSK3β影响WSSV基因表达及复制等四方面的研究，阐明GSK3β介导NFκB调控WSSV基因表达及复制的分子作用机制。通过本研究可进一步完善对虾抗病免疫机理，为增强对虾的自身免疫力，提高其抗病能力提供理论依据，为建立有效的WSS防控技术奠定基础。

Shrimp is the major species of aquaculture in China. In 2015, the total production was about 1, 900, 000 tons, while the production of Litopenaeus vannamei accounted for more than 85%. White spot syndrome(WSS) is the main bottleneck factors that affect China's shrimp aquaculture development. WSS is caused by white Spot Syndrome Virus (WSSV), one of the most serious infectious virus appeared in shrimp farming in recent years. In this study, we will try to clarify the molecular mechanisms of WSSV gene expression and replication regulated by Glycogen synthase kinase 3β(GSK3β) mediating nuclear factor κB(NFκB) in Litopenaeus vannamei based on the following four aspects: (1) Regulation of NFκB by GSK3β, (2) Regulation of IκB by GSK3β, (3)Regulation of GSK3β by NFκB, (4) GSK3β effects on WSSV gene expression and replication. The results could perfect the immune mechanism and then provide theoretical basis for enhancing the immunity and improving the disease resistance of shrimp. Hoping to lay the foundation for the establishment of effective prevention and control technology against to WSS.