Merrilactone A 和11-O-debenzoyltashironin的简洁全合成

提取自滇缅八角的稀有天然产物(-)-merrilactone A 和(-)-11-O-debenzoyltashironin 在八角属萜类中结构最为特殊，且表现出显著神经营养活性和神经保护活性，具有抗帕金森氏症和阿尔茨海默症的应用潜力。本项目拟发展由对称的双γ-丁内酯的去对称化出发的通用策略，以及若干立体选择性新合成方法，实现这两种天然产物的最简洁对映选择性全合成，为八角属萜类对神经退行性疾病的机理与治疗药物研究提供化学合成技术支撑。

(-)-Merrilactone A and (-)-11-O-debenzoyltashironin isolated from Illicium merrillianum are rare sesquiterpenes with significant neurotrophic and neuroprotective activities. The unique caged polycyclic structural features and the potential on treating Parkinson’s disease and Alzheimer’s disease make them hot molecules for total synthesis study. Herein, we proposed the most concise route for enantioselective total syntheses of these two compounds via communal strategy based on the desymmetrization of symmetrical bis-γ-butyrolactone and de novo stereoselective synthetic methodologies. Our research will facilitate the application of Illicium terpenes in therapeutic agents development and mechanism study toward neurodegenerative diseases.