锆基非晶合金高速加工呈现粘性、晶化、熔化以及燃烧与发光等玻璃态物质独特变形与加工特征，严重制约其在高端微创手术器械的应用。本项目研究真空压铸大块医用锆基非晶合金的玻璃形成机制、形成能力及影响因素，建立合金成分-玻璃形成能力-生物相容性-可加工性的关联机制，实现大块医用锆基非晶合金压铸成型；建立加工变形-温度协同驱动晶化动力学模型，揭示多重复杂热力耦合变形与加工动态晶化本质规律；阐释玻璃态物质机加工特有现象的发生机制；研究基于加工温度和应力控制的表面无晶化精密加工工艺；建立电解质等离子抛光去除机理和表面完整性模型，实现高效可控表面无晶化抛光。研究典型微创手术器械与生物组织的切割分离、抓取、夹持机制；建立超锋利不锈手术刀、无损血管夹和精准牢固微创缝合抓钳等锆基非晶合金微创手术器械的精密高效设计、制造与临床应用理论、工艺和评价体系；促进玻璃态物质加工与生物制造理论发展，提高高端微创手术器械水平。

Zirconium-based amorphous alloy is severely constrained to apply in the field of high-end minimally invasive surgical instruments due to the special deformation and cutting characteristic during high speed machining process，such as viscous, crystallization, melting, burning and glowing. In this project, the glass forming mechanism, formation ability and influencing factors of vacuum die-casting large-scale medical zirconium-based amorphous alloy will be studied. And large size of medical Zirconium-based bulk metallic glass will be fabricated after the relationship of alloy composition-glass forming ability-biocompatibility-processability is established.The crystallization kinetics model driven by deformation and temperature will be established to reveal the muti-complex thermodynamic coupling deformation and processing dynamic crystallization essence. The machining mechanism of the glassy will be explained.Then, the precision machining process without crystallization based on the control of machining temperature and stress will be also researched . The mechanism of electrolytic plasma polishing of Zirconium-based bulk metallic glass and the surface integrity model will be established to get high efficient and no crystallization surface polishing in controllable way. Finally, this project studies the separation, gripping and clamping mechanism between typical minimally invasive surgical instruments and biological tissues. On the basis of Zirconium-based bulk metallic glass minimally invasive surgical instruments, such as ultra-sharp stainless scalpel, lossless of blood vessel clamp and precise suture grasping pliers, the precision and efficient design, fabrication and clinical application theory, manufacturing process and evaluation system will be established to develop the theory of glassy material processing and improve the level of high-end minimally invasive surgical medical instruments.