设计集选择性识别、成像及杀伤性能于一体的多功能新材料对于重大疾病治疗具有重要意义。本项目充分发挥化学与生物学科交叉研究的优势，主要研究方向是设计、发展新型的集选择性识别、成像及杀伤性能于一体的多功能抗肿瘤以及抗菌共轭聚合物复合材料新体系。具体研究内容如下：（1）设计、合成、表征系列不同主链与侧链结构的共轭聚合物材料，构建共轭聚合物-金属配合物（或量子点）杂化材料体系，研究它们与细胞的相互作用、材料的生物相容性以及这些体系中的重要生物信息；（2）研究共轭聚合物复合材料体系敏化产生活性氧（ROS）过程的机理并分析ROS种类对肿瘤细胞与病原菌的杀伤活性；（3）设计具有靶向识别与成像能力的共轭聚合物光动力治疗新体系；（4）发展无需外界光源的共轭聚合物光激活抗肿瘤与抗菌新体系。该项目不仅可以发展新型的具有抗肿瘤以及抗菌活性的共轭聚合物复合材料体系，而且可以为克服药物耐药性以及重大疾病治疗提供新思路。

Design of novel materials with the functions of selective recognition, imaging and killing capabilities is of great significance on fighting against drug resistance and treatment of major diseases. This project will focus on the design and development of multifunctional conjugated polymer materials with selective recognition, imaging and cell-killing ability. The main research work includes: (1) To design a series of conjugated polymer materials and conjugated polymer-nanoparticles (such as, quantum dots ), further study their interactions with cells, biological compatibility and the information associated with the biological process of these systems; (2) To study the generation mechanism of reactive oxygen species (ROS) from oxygen molecules sensitized by conjugated polymer materials and the killing activity of different ROS; (3) To design photodynamic therapy (PDT) systems based on conjugated polymers with targeted identification and imaging capability; (4) To design novel light-activated targeted antitumor and antibacterial systems without requirement of outside light irradiation. This project not only can obtain new conjugated polymer systems with anti-tumor and anti-microbial activities, but also provide new concepts and technology to fight against drug resistance for the treatment of major diseases.