生物体系功能的可控调控对研究生命过程以及重大疾病防治都具有重要的意义。本项目充分发挥化学、生物和医学交叉研究的优势，围绕光响应聚合物体系的设计以及调控细胞生物学功能展开工作。主要研究工作包括：制备外界刺激响应（光、pH 以及生物、化学分子）的功能聚合物，构建新型的聚合物与细胞的组装体系，利用光、pH 以及生物、化学分子刺激，研究聚合物与细胞的相互作用过程，实现对细胞间通讯的调控；通过控制聚合物的尺寸、构型、识别模式研究其与细胞表面受体的可控组装，实现对细胞信号通路的可控调控。本项目既可以发展功能导向的化学组装新体系和新技术，又可以为通过生物物理化学方法与技术调控细胞生物功能提供理论与实验基础。

The controllable function regulation of biological systems through chemical or biological technology is of great significance on understanding the life processes and the prevention and treatment of major diseases. Taking the interdisciplinary advantage of chemical, biological and medical studies, this project will focus on the design of responsive polymer systems and the regulation of cell biological function. The main research work includes: 1) preparing external stimuli-responsive(light, pH and biological and chemical molecules) functional polymers for constructing new polymer-cell assembly system; 2) regulating intercellular communications by assembly and disassembly processes of polymer with cells; 3) tuning polymer size, configuration and recognition format to control their accurate interactions with cell surface receptors, and to realize controlled regulation of cell signaling pathways. This project not only can develop function directed new system and new technology of self-assembly,but also can provide theoretical and experimental basis for the cell biological function regulation through biophysical chemical technique.