基于氨基酸的有机催化剂设计、合成及其应用

本课题基于酶催化反应原理，从酶最基本的结构单元氨基酸出发经过简单化学转化，设计、合成具有酶催化剂优点的结构多样性、多官能团协同催化的有机小分子催化剂；探索新催化机理、设计、合成新型催化剂以及发展新的有机催化反应及其规律性；重点开展高效、高对映选择性催化不对称碳-碳（杂原子）键形成反应、不对称环加成、一步形成多个手性中心的多组分串联反应的研究；同时开发催化反应的新概念、策略和新方法，发展新型的不对称小分子催化导向的复杂天然产物的全合成。

Based on the principle of enzyme-catalyzed reactions, structurally diversified and polyfunctional organic small molecule cooperative catalysts will be designed, synthesized starting from the basic structural unit of the enzyme-amino acids; which have the advantage of enzyme catalysts. This project will explore new catalytic mechanism, design, synthesis of novel catalysts and catalytic reactions to develop new organic reactions and mechanism; focus on efficient, enantioselective catalytic asymmetric carbon - carbon (hetero) bond forming reactions, asymmetric cycloaddition, the multi-component reaction forming multiple chiral centers in one step; develop new concept, the reaction new strategies and new methods; perform new catalytic asymmetric oragnocatalytic reaction directed the total synthesis of complex natural products.