氨基酸衍生的手性离子对催化不对称反应及其应用

本项目主要开展基于氨基酸的手性离子对导向催化：催化剂设计、合成及应用。从氨基酸出发经过简单化学转化，设计、合成具有酶催化剂优点的结构多样性、多官能团协同催化的有机手性离子对催化剂；探索离子对导向催化的反应、机理、策略及其规律性；重点开展高效、高对映选择性催化不对称碳-碳（杂原子）键形成反应和不对称串联环化加成的研究；同时将离子对催化反应的新概念、策略和新方法应用于生物活性楝酰胺类天然产物的全合成。

This project mainly conducts amino acid-based chiral ion pair-directed catalysis: catalyst design, synthesis and application. Starting from simple amino acid, we will design and synthesize a variety of structural catalysts with the advantages of enzyme catalysts, and cooperative organic chiral ion pairs with multi-functional groups through chemical transformations. We also explored the reaction, mechanism, strategy and regularity of ion-pairing directed catalysis. We will focus on highly efficient, enantioselective catalytic asymmetric carbon-carbon (heteroatom) bond formation reaction and asymmetric tandem cyclization addition; the new concept of ion-pair catalytic reaction strategy and new methods will be applied in total synthesis of bioactive rocaglamide natural product.