本项目的主要目标就是利用各种联用技术包括高效液相色谱-电感耦合等离子体质谱联用技术、离子色谱-电感耦合等离子体质谱联用技术和毛细管电泳-电感耦合等离子体质谱联用技术对我国主要食用海藻中的砷糖化合物进行形态分析。并在此基础上，利用现代色谱分离技术对主要食用海藻中占主导地位的砷糖化合物进行分离和纯化，然后利用质谱、红外光谱、核磁共振等技术对主要食用海藻中占主导地位的砷糖化合物的化学结构进行表征，了解我国主要食用海藻中占主导地位砷糖化合物的化学形态特征。并通过动物（小鼠）实验，详细、系统研究不同食用海藻中占主导地位的不同化学结构的砷糖化合物在动物体内的化学变化和代谢情况，以期为更加客观、科学评价不同种类食用海藻的砷污染风险提供新的理论依据和技术支撑，保证海藻类食品的消费安全。

The main purpose of this study is to determine different arsenic species including arsenosugars in the main edible seaweeds, which collected from China, by using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICP-MS) or ion chromatography-inductively coupled plasma mass spectrometry (IC-ICP-MS) or capillary electrophoresis-inductively coupled plasma mass spectrometry (CE-ICP-MS). And on this basis, we will further to separate the dominant arsenosugars from different edible seaweeds for characterizing their chemical structure with mass spectrometry, infrared spectrometry and nuclear magnetic resonance (NMR), in order to comprehend the chemical species characteristics of arsenosugars existing in different edible seaweeds. Based on above experimental results, the altering of chemical structure and metabolism of different arsenosugars in animal body will be investigated in detail with animal experiments, which using mouse as target. The experimental results of this study will provide novel theoretical evidences and technical support for assessing the risk of arsenic contamination in different edible seaweeds more objectively and scientifically, and ensuring the consumption safety of different edible seaweeds.