太赫兹(THz)波段光子能量与生物分子运动及互作能级的匹配性，使得THz生物效应特别是其在体生物效应成为其生物医学应用中的重要领域。太赫兹自由电子激光装置(CTFEL)的高功率和大光斑优势为THz在体生物效应研究提供了必要的保障。在THz对人体关节炎缓解效果和我们前期发现THz可调节小鼠炎症因子水平的基础上，本项目分别以正常和类风湿关节炎(RA)小鼠为模型，探索THz对正常和疾病小鼠的免疫调节作用及对炎症反应的干预效果，揭示THz在RA炎性疾病干预过程中应用的有效性及分子机制。通过辐照区域皮肤组织应激程度和响应机制的研究，揭示CTFEL高峰值功率辐照的生物安全性。这些机体在THz辐照下经由免疫系统表现出的全身系统效应及辐照局部的直接效应的揭示，能极大地丰富THz在体生物效应领域的研究，也是THz生物技术走向应用所必需的基础研究工作，具有很强的学术创新性、理论意义和潜在的应用价值。

The energy of THz photons matches with the energy levels of biomolecular motion and interaction, which makes THz biological effect, especially its in vivo biological effect, an important field for THz biomedical applications. The advantages of high power and large facula of CTFEL apparatus provide a important guarantee for the THz in vivo bio-effects study. Based on the alleviating effect of THz on human arthritis previous reported by domestic scholar and our discovery that THz could regulate the inflammatory factors level in mice, we are going to explore the immunoregulatory effect of THz in healthy and rheumatoid arthritis (RA) mice in this study. The intervening effect, the effectiveness and the molecular mechanisms of THz on inflammatory response of RA will be investigated. By revealing the stress response level of skin tissue as well as the relative mechanism, the biosafety of the high peak power irradiation generated by CTFEL will also be illustrated. The systemic effects performed via immune system and the local skin tissue direct effects of THz irradiation uncovered by this study can greatly enrich the in vivo THz bio-effects study to a large extent. It is the most basic research with great necessity for the development and practical application of THz biotechnology, which has strong academic innovativeness, theoretical significance and potential application value.