环境污染物可在生物体内积累并且传递给子代，而早期生命阶段对污染物的暴露非常敏感，并且可能与成年期的疾病发生和健康有关。拟除虫菊酯是人工仿生合成的模拟天然除虫菊素的一类杀虫剂，广泛应用于农作物和卫生害虫的防治中，由于其使用量不断增加，日渐引起人们对其导致的环境污染与人类安全问题的关注。再者，拟除虫菊酯不同对映体在生物过程中存在较大的差异。因此，本研究以斑马鱼为对象，分别进行联苯菊酯外消旋体和两种对映体的长期暴露，分析联苯菊酯对映体在母体和子代中的蓄积特征差异，研究其通过母体传递至子代的过程和效应，评价联苯菊酯母体暴露对子代神经系统发育的影响，阐明手性农药对斑马鱼母代传递毒性效应的对映体选择性，并探索可能的分子机制。本项目将揭示联苯菊酯对映体选择性的母代传递效应以及对子代神经发育的毒性和机制，为全面评价拟除虫菊酯的环境健康风险提供理论依据。

Bioaccumulation of environmental contaminants and subsequent maternal transfer to offspring has been recognized as a significant contributing factor in the development of offspring health and disease. The pyrethroids are a class of synthetic insecticides that have been designed based on the structures of natural insecticide pyrethrum and widely used for agricultural and indoor pest control. The elevated concentrations of application in many locations have raised considerable human health and environmental concern. Moreover, as the most important one chiral pesticides, different enantiomers of pyrethroids showed significant enantioselectivity in biological processes. Therefore, we examined the impact of long-term, racemate and two enantiomer of bifenthrin (1S-cis-bifenthrin and 1R-cis-bifenthrin) exposure on zebrafish. The objectives of this study were to investigate: 1) the chemical accumulation of bifenthrin in parental (F0) zebrafish and to investigate its transfer to offspring; 2) the effects of bifenthrin on neurodevelopment in F1 larvae; and 3) the enantioselectivity in the bio-accumulation in the F0 and F1 generation as well as transfer toxic effects of bifenthrin. Taken together, the results of our study further elucidate the environmental risks of pyrethroids to aquatic ecosystems and potential health effects.