主动脉夹层/主动脉瘤是严重的致死性极高的疾病，以基质降解为主要病理特点，病因和发病机制不明。本项目组整合了临床与遗传研究、血管基质及蛋白组学优势的课题组，对大样本主动脉夹层和动脉瘤病人进行深度测序，初步找到了某些新的致病/可能致病的基质相关基因，拟在模式动物中研究验证；对人主动脉夹层/动脉瘤血管组织和模式动物组织进行蛋白质组学分析，深入研究细胞外基质结构和功能变化而导致大血管病变及夹层和动脉瘤形成的机制。研究结果将从血管基质角度，深入揭示新的致病基因并阐明致病机制，这将为这一重大主动脉疾病的风险预测与预防提供依据，为进一步研究新的防治手段提供理论基础。

Aortic dissection/aortic aneurysm was a serious and fatal disease, characterized by degration of matrix, of which etiology and pathogenesis were unknown. This new project group merged clinical and genetic studies group, vascular matrix group and proteomics group. This group aims to use deep sequencing technology of aortic dissection/aortic aneurysm in large patient sample to find new pathogenic/possible pathogenic genes on artery matrix, by using model animals for validation. This project aims to study the mechanism of macroangiopathy and aortic dissection/aneurysm formation which comes from variety in extracellular matrix structure and function by gene mutation, by using proteomic analysis of human aortic dissection/aneurysm and model animals’ vascular tissue. This study can reveal the pathogenicity gene and mechanism of aortic dissection / aneurysm. This study can provide the theoretical basis to risk prediction of aortic disease and further study in new prophylaxis and treatment.