电响应的仿生智能界面的构建及其应用

能够随着外界刺激的变化而改变表面性质的智能界面在过去的几年中吸引力了大量的研究兴趣。能够调节生物分子活性、蛋白质固定、细胞粘附和迁移的智能界面可以在生物和医学领域有相当广泛的应用。目前的研究成果中，所施加的外界刺激有温度、pH、光照、电等。其中，电响应因其操作方便、成本低、灵敏度高、对细胞无伤害、可监控表面官能团变化等优势被广泛应用。而以往构建的电响应的智能仿生界面，均是以不同手段达到生物活性基团的固定或脱除，隐藏或裸露，很少有研究这些生物活性分子在不同状态（构象变化、结构变化等）时对细胞粘附、迁移或分化等行为的作用。而生物体系中，生物活性分子的不同状态确实会对表面与细胞的相互作用产生相当大的影响，因此，需要构建更加复杂的智能表面来模拟不同的生物环境，来研究这些影响。

Surfaces with stimuli-responsive properties, also known as smart surfaces, have attracted substantial research interest in the past few years. Surfaces that can modulate biomolecule activity, protein immobilization, and cell adhesion and migration, at the liquid–solid interface can be tremendously useful in diverse biological and medical applications. In the recent researches, the stimuli consists of temperature, pH, photo and electrical and so on. The electrical-responsive smart surfaces are widely used due to their advantages: easy operation, low cost, high sensitivity, cell harmless, monitor of surface functional group and so on. The previous work that constructed smart surface, are based on the modification/removal and hidden or exposed, through different means. Few work research the effects of the different states of bio-molecules (conformation, structure etc.) on the cell adhesion, migration and differentiation. However, in the biological systems, different states of bio-molecules indeed have a considerable impact on interaction between cell and surface. Therefore, it is necessary to construct more complex smart surface to simulate different biological environment.