植物代谢包括糖酵解易受环境干扰，盐胁迫能使得植物体内H2O2积累，影响植物代谢，抑制植物的生长发育。但是盐胁迫如何影响代谢进而调控胁迫应答机制并不清楚。我们的前期研究表明盐胁迫应能积累H2O2，影响糖酵解和积累MG并修饰靶蛋白，进而抑制开花和促进胁迫应答基因表达。因此，我们将继续研究，明确证明在盐胁迫下H2O2通过修饰糖酵解酶磷酸丙糖异构酶的半胱氨酸，抑制其酶活而积累MG；MG又通过修饰其靶蛋白参与植物盐胁迫应答。清晰阐明MG是通过修饰并稳定DELLA，抑制植物开花基因表达而致植物晚花；另一方面，植物利用MG修饰组蛋白H3调控胁迫应答基因转录，提高植物对盐胁迫的耐受性。我们的研究将明晰盐胁迫调控糖酵解的分子机制，明确证明MG是表观遗传修饰新分子并调控盐胁迫应答基因表达。研究成果能加深人们对植物体内代谢变化与外部环境协同机制的了解，完善植物盐胁迫应答调控网络，为农作物的耐盐能力改良提供依据。

It is known that metabolism including glycolysis is easily disturbed by the environment in plants and salt stress-mediated hydrogen peroxide (H2O2) accumulation can inhibit plant growth and development by affecting metabolism. But, how salt stress modulates sugar metabolism to affect plant growth via H2O2 remains unknown. To address it, we have performed the experiments and indicated that salt stress can regulate glycolysis by promoting H2O2 accumulation, leading to methylglyoxal (MG) accumulation. The accumulated MG further modify its target proteins for delayed flowering and promoted expression of stress response genes. In this project, we plan to carry out further experiments to demonstrate that salt stress-increased H2O2 can sulfenylate the cysteine residue of plastid isoform of triose phosphate isomerase (pdTPI), in turn, inhibit its enzymatic activity, and thus, result in the higher MG accumulation in salt-stressed Arabidopsis plants. Our study will also show that the stabilized DELLA through MG modification represses the expression of FT and SOC1 for delayed flowering. In addition, our data will demonstrate that MG can promote the expression of stress response genes by modifying H3 in salinity-stressed plants. Therefore, our study will elucidate the biochemical and molecular mechanisms of glycolysis reprogramming under salt stress, verify MG as a novel epigenetic modifier operating in plant salt stress responses. The research results can deepen our understanding of the synergistic mechanism of metabolism and environment, improve the regulation network of plant salt stress response, and provide a reference for improving the salt tolerance of crops.