Adult outcomes of youth irritability: a 20-year prospective community-based study.
Adult outcomes of youth irritability: a 20-year prospective community-based study.
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DOI：
10.1176/appi.ajp.2009.08121849
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Leibenluft E
中科院分区：
文献类型：
--
作者：
Stringaris A;Cohen P;Pine DS;Leibenluft E
烦躁是青少年中广泛出现的 DSM-IV 症状。然而，人们对早年烦躁与其中年后果之间的关系知之甚少。这项研究通过检验青少年烦躁可预测抑郁症和广泛性焦虑症的假设，探讨了青少年烦躁与成人精神结局的相关程度。作者对 631 名参与者进行了一项纵向社区研究，这些参与者的父母在青春期早期（平均年龄=13.8 岁 [SD=2.6]）时接受了采访，而他们自己在 20 年后接受了采访（平均年龄=33.2 岁[SD=2.9]）。父母报告的青春期烦躁情绪被用来预测自我报告的精神病理学，并通过 20 年随访时的标准化诊断访谈进行评估。从横截面来看，青春期的烦躁与其他精神疾病广泛相关。调整基线情绪和行为障碍后，青春期的烦躁可预测重度抑郁症（比值比=1.33，95%置信区间[CI]=1.00–1.78]）、广泛性焦虑症（比值比=1.72，95% CI=1.04–2.87）和心境恶劣（比值比=1.81，95%） 20 年随访时 CI=1.06–3.12。随访时青少年的烦躁并不能预测双相情感障碍或 II 轴疾病。父母报告的青少年易怒是 20 年后自我报告的抑郁症和焦虑症的具体预测因素。烦躁在发展精神病学中的作用，特别是在情绪和焦虑症的病理生理学中的作用，应该得到进一步的研究。
Irritability is a widely occurring DSM-IV symptom in youths. However, little is known about the relationship between irritability in early life and its outcomes in mid-adulthood. This study examines the extent to which youth irritability is related to adult psychiatric outcomes by testing the hypothesis that it predicts depressive and generalized anxiety disorders. The authors conducted a longitudinal community-based study of 631 participants whose parents were interviewed when participants were in early adolescence (mean age=13.8 years [SD=2.6]) and who were themselves interviewed 20 years later (mean age=33.2 years [SD=2.9]). Parent-reported irritability in adolescence was used to predict self-reported psychopathology, assessed by standardized diagnostic interview at 20-year follow-up. Cross-sectionally, irritability in adolescence was widely associated with other psychiatric disorders. After adjustment for baseline emotional and behavioral disorders, irritability in adolescence predicted major depressive disorder (odds ratio=1.33, 95% confidence interval [CI]=1.00–1.78]), generalized anxiety disorder (odds ratio=1.72, 95% CI=1.04–2.87), and dysthymia (odds ratio=1.81, 95% CI=1.06–3.12) at 20-year follow-up. Youth irritability did not predict bipolar disorder or axis II disorders at follow-up. Youth irritability as reported by parents is a specific predictor of self-reported depressive and anxiety disorders 20 years later. The role of irritability in developmental psychiatry, and in the pathophysiology of mood and anxiety disorders specifically, should receive further study.
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影响因子：
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