The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma.
The value of diffusion-weighted imaging in assessing the ADC changes of tissues adjacent to breast carcinoma.
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DOI：
10.1186/1471-2407-9-18
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发表时间：
2009-01-14
期刊：
影响因子：
3.8
通讯作者：
Youmin G
中科院分区：
文献类型：
--
作者：
Yili Z;Xiaoyan H;Hongwen D;Yun Z;Xin C;Peng W;Youmin G
定义乳腺恶性病变与良性病变的表观弥散系数（ADC）阈值，并应用超声平面弥散加权成像（EPI-DWI）评价乳腺癌肿瘤周围组织的ADC变化。57例乳腺病变行常规MRI及EPI-DWI扫描。比较良、恶性病变的ADC值。采用受试者工作特征曲线（Receiver Operating Characteristic curve， ROC）评价EPI-DWI及阈值ADC的敏感性和特异性。比较不同方向恶性病变与层状肿瘤周围组织（从最内层1到最外层4，每层5mm）的ADC值，并比较不同层间的ADC值。35例恶性病变的ADC值低于22例良性病变（P < 0.05）。ROC曲线的阈值为1.24 +/- 0.25*10E-3 mm2/s （b = 500）或1.20 +/- 0.25*10E-3 mm2/s （b = 1000）。在不同方向上，恶性病变的ADC值均低于肿瘤周围组织的ADC值（P < 0.05）。肿瘤周围组织从第1层到第4层ADC值逐渐升高，第1层与第2层ADC值差异有统计学意义（P < 0.05）；而从第2层向外，各层间无统计学差异。ADC值是鉴别乳腺良恶性病变的一个敏感而特异的参数。EPI-DWI可以检测乳腺癌旁组织ADC的变化，这使得EPI-DWI成为帮助确定乳腺癌手术范围的一种很有前景的方法。
To define a threshold value of apparent diffusion coefficient (ADC) with which malignant breast lesions can be distinguished from benign lesions, and to evaluate the ADC change of peri-tumor tissue in breast carcinoma by echo planar-diffusion weighted imaging (EPI-DWI). 57 breast lesions were scanned by routine MRI and EPI-DWI. The ADC values were compared between malignant and benign lesions. The sensitivity and specificity of EPI-DWI and the threshold ADC value were evaluated by Receiver Operating Characteristic curve (ROC). The ADC values of malignant lesion and layered peri-tumor tissues (from innermost layer 1 to outermost layer 4 with 5 mm every layer) in different directions were compared and the ADC values among different layers were compared. The ADC value of 35 malignant lesions was statistically lower than that of 22 benign lesions (P < 0.05). In ROC curve, the threshold value was 1.24 +/- 0.25*10E-3 mm2/s (b = 500) or 1.20 +/- 0.25*10E-3 mm2/s (b = 1000). The ADC value of malignant lesions was statistically lower than that of peri-tumor tissues in different directions (P < 0.05). For peri-tumor tissues, the ADC values increased gradually from layer 1 to layer 4 and there was a significant difference between the ADC values of layer 1 and layer 2 (P < 0.05); while from layer 2 outwards, there was no statistical difference among different layers. ADC value was a sensitive and specific parameter that could help to differentiate benign and malignant breast lesions. ADC changes in tissues adjacent to breast carcinoma could be detected by EPI-DWI, which made EPI-DWI a promising method for helping to determine surgical scope of breast carcinoma.
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DOI：
10.2463/mrms.1.73
发表时间：
2002-07-01
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Kuroki, Yoshifumi;Nawano, Shigeru;Hayashi, Takayuki
通讯作者：
Hayashi, Takayuki
影响因子：
4.4
作者：
Rumpel, H;Khoo, JBK;Tan, KP
通讯作者：
Tan, KP
影响因子：
4.3
作者：
Pan, Zhi-Zhong;Wan, De-Sen;Wang, Fu-Long
通讯作者：
Wang, Fu-Long
影响因子：
4.4
作者：
Guo, Y;Cai, YQ;Gao, JH
通讯作者：
Gao, JH
DOI：
10.2463/mrms.3.79
发表时间：
2004-07-15
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Kuroki, Yoshifumi;Nasu, Katsuhiro;Nawano, Shigeru
通讯作者：
Nawano, Shigeru