Medial prefrontal theta phase coupling during spatial memory retrieval.
Medial prefrontal theta phase coupling during spatial memory retrieval.
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DOI：
10.1002/hipo.22255
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发表时间：
2014-06
期刊：
影响因子：
3.5
通讯作者：
Burgess, Neil
中科院分区：
文献类型：
--
作者：
Kaplan, Raphael;Bush, Daniel;Bonnefond, Mathilde;Bandettini, Peter A.;Barnes, Gareth R.;Doeller, Christian F.;Burgess, Neil
记忆提取被认为涉及不同的区域网络，包括内侧前额叶和内侧颞叶皮层，但它们协调的机制仍然难以捉摸。一个建议是，振荡的连贯性介导区域间的通信，暗示θ相位和θ-γ相位振幅耦合在跨物种的记忆功能。为了验证这一假设，我们使用了非侵入性的全头脑磁图（MEG）作为参与者检索在虚拟环境中遇到的物体的位置。我们证明，当参与者与一个对象的位置，他们必须随后导航到的图像提示，有一个显着增加4-8 Hz的θ功率内侧前额叶皮层（mPFC），这种振荡的相位耦合都与正在进行的θ相位内侧颞叶（MTL）和内侧顶叶皮层的感知诱导65-85 Hz的伽马振幅。这些结果表明，theta相位mPFC和MTL之间的耦合和theta-gamma相位振幅mPFC和新皮层区域之间的耦合可能在人类空间记忆提取中发挥作用。版权所有© 2014作者.出版社：Wiley Periodicals，Inc.
Memory retrieval is believed to involve a disparate network of areas, including medial prefrontal and medial temporal cortices, but the mechanisms underlying their coordination remain elusive. One suggestion is that oscillatory coherence mediates inter-regional communication, implicating theta phase and theta-gamma phase-amplitude coupling in mnemonic function across species. To examine this hypothesis, we used non-invasive whole-head magnetoencephalography (MEG) as participants retrieved the location of objects encountered within a virtual environment. We demonstrate that, when participants are cued with the image of an object whose location they must subsequently navigate to, there is a significant increase in 4–8 Hz theta power in medial prefrontal cortex (mPFC), and the phase of this oscillation is coupled both with ongoing theta phase in the medial temporal lobe (MTL) and perceptually induced 65–85 Hz gamma amplitude in medial parietal cortex. These results suggest that theta phase coupling between mPFC and MTL and theta-gamma phase-amplitude coupling between mPFC and neocortical regions may play a role in human spatial memory retrieval. © 2014 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
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