Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.
Evaluation of retinal and choroidal thickness by swept-source optical coherence tomography: repeatability and assessment of artifacts.
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DOI：
10.1016/j.ajo.2014.02.008
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发表时间：
2014-05
影响因子：
4.2
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Mansouri K;Medeiros FA;Tatham AJ;Marchase N;Weinreb RN
确定扫描源光学相干断层扫描（SS OCT）自动视网膜和脉络膜厚度测量的可重复性以及扫描伪影的频率和类型。新诊断技术的前瞻性评价。前瞻性招募了30名健康受试者，并使用原型SS OCT仪器进行成像。对27例受试者（平均年龄35.1 ± 9.3岁）的54只眼进行了未散瞳扫描。每例受试者接受4个SS OCT方案，重复3次：视盘和黄斑的三维（3D）6 × 6 mm光栅扫描、放射状扫描和线扫描。通过分割软件获得自动测量。通过组内相关系数（ICC）评估扫描间重复性。三维黄斑、三维视盘、放射线和线扫描的脉络膜测量ICC分别为0.92、0.98、0.80和0.91。视网膜测量的ICC分别为0.39、0.49、0.71和0.69。伪影存在于高达9%的扫描中。由于眨眼导致的信号丢失是3D扫描中最常见的伪影（视盘扫描，7%;黄斑扫描，9%），而放射状扫描和线扫描中分别有4%和3%出现分割失败。当排除图像伪影扫描时，3D黄斑、3D视盘、放射状和线扫描的脉络膜厚度ICC分别增加至0.95、0.99、0.87和0.93。视网膜厚度的ICC分别增加至0.88、0.83、0.89和0.76。在校正扫描伪影后，发现SS OCT自动脉络膜和视网膜厚度测量的可重复性得到改善。识别扫描伪影对于正确解释SS OCT测量结果非常重要。
To determine the repeatability of automated retinal and choroidal thickness measurements with swept-source optical coherence tomography (SS OCT) and the frequency and type of scan artifacts. Prospective evaluation of new diagnostic technology. Thirty healthy subjects were recruited prospectively and underwent imaging with a prototype SS OCT instrument. Undilated scans of 54 eyes of 27 subjects (mean age, 35.1 ± 9.3 years) were obtained. Each subject had 4 SS OCT protocols repeated 3 times: 3-dimensional (3D) 6 × 6-mm raster scan of the optic disc and macula, radial, and line scan. Automated measurements were obtained through segmentation software. Interscan repeatability was assessed by intraclass correlation coefficients (ICCs). ICCs for choroidal measurements were 0.92, 0.98, 0.80, and 0.91, respectively, for 3D macula, 3D optic disc, radial, and line scans. ICCs for retinal measurements were 0.39, 0.49, 0.71, and 0.69, respectively. Artifacts were present in up to 9% scans. Signal loss because of blinking was the most common artifact on 3D scans (optic disc scan, 7%; macula scan, 9%), whereas segmentation failure occurred in 4% of radial and 3% of line scans. When scans with image artifacts were excluded, ICCs for choroidal thickness increased to 0.95, 0.99, 0.87, and 0.93 for 3D macula, 3D optic disc, radial, and line scans, respectively. ICCs for retinal thickness increased to 0.88, 0.83, 0.89, and 0.76, respectively. Improved repeatability of automated choroidal and retinal thickness measurements was found with the SS OCT after correction of scan artifacts. Recognition of scan artifacts is important for correct interpretation of SS OCT measurements.
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