Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer.
Matrix metalloproteinase-2 is a consistent prognostic factor in gastric cancer.
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DOI：
10.1038/sj.bjc.6603041
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发表时间：
2006-04-10
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
在10年前的一项开创性研究中，我们表明，酶谱检测显示，胃癌组织中基质金属蛋白酶(MMPs)MMP2和MMP9的水平升高与患者总体生存状况较差有关。为了证实这些观察结果，我们现在用新技术在一组扩大的胃癌患者(n=81)中评估了基质金属蛋白酶-2和基质金属蛋白酶-9，并将基质金属蛋白酶-7、基质金属蛋白酶-8和基质金属蛋白酶的组织抑制物、基质金属蛋白酶-1和基质金属蛋白酶-2进行比较。与正常胃粘膜相比，肿瘤组织中MMPs和TIMP-1均显著升高。基质金属蛋白酶-7、-8、-9和TIMPs与临床病理参数TNM、WHO和Laurén分级有一定的相关性，但与生存期无关。无论采用何种检测方法，即酶联免疫吸附试验或生物活性测定，肿瘤基质金属蛋白酶-2水平升高与任何临床病理参数均无显著相关性，但已被证实是胃癌的一个独立预后因素。
In a pioneer study, we showed 10 years ago that enhanced tissue levels of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9 in gastric cancers, as determined by zymography, were related with worse overall survival of the patients. To corroborate these observations, we now assessed MMP-2 and MMP-9 with new techniques in an expanded group of gastric cancer patients (n=81) and included for comparison MMP-7, MMP-8 and the tissue inhibitors of MMPs, TIMP-1 and -2. All MMPs and TIMP-1 were significantly increased in tumour tissue compared to normal gastric mucosa. Matrix metalloproteinase-7, -8 and -9, and the TIMPs showed some correlations with the clinicopathologic parameters TNM, WHO and Laurén classification, but their levels were not related with survival. Regardless of the determination method used, that is, enzyme-linked immunosorbent assay or bioactivity assay, an enhanced tumour MMP-2 level did not show a significant correlation with any of the clinicopathological parameters, but was confirmed to be an independent prognostic factor in gastric cancer.
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影响因子：
3.3
作者：
Kabashima, A;Yao, T;Tsuneyoshi, M
通讯作者：
Tsuneyoshi, M
DOI：
10.1007/s101200050008
发表时间：
1998-03-01
期刊：
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
影响因子：
--
作者：
Torii, Akihito;Kodera, Yasuhiro;Kito, Tsuyoshi
通讯作者：
Kito, Tsuyoshi
影响因子：
11.4
作者：
Itoh, Y;Takamura, A;Seiki, M
通讯作者：
Seiki, M
影响因子：
8.8
作者：
Sier CF;Kubben FJ;Ganesh S;Heerding MM;Griffioen G;Hanemaaijer R;van Krieken JH;Lamers CB;Verspaget HW
通讯作者：
Verspaget HW
DOI：
10.1111/j.1349-7006.2002.tb02171.x
发表时间：
2002-03
期刊：
Japanese journal of cancer research : Gann
影响因子：
--
作者：
Liu XP;Kawauchi S;Oga A;Tsushimi K;Tsushimi M;Furuya T;Sasaki K
通讯作者：
Sasaki K