Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria.
Enhanced hippocampus-dependent memory and reduced anxiety in mice over-expressing human catalase in mitochondria.
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DOI：
10.1111/jnc.12187
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发表时间：
2013-04
影响因子：
4.7
通讯作者：
Raber J
中科院分区：
文献类型：
--
作者：
Olsen RH;Johnson LA;Zuloaga DG;Limoli CL;Raber J
氧化应激（OS）和活性氧（ROS）在突触可塑性和信号通路中发挥调节作用。线粒体 (MT) 是 ROS 的主要来源，因为它们参与能量代谢，对大脑功能很重要。 MT 产生的 ROS 被认为是 OS 的重要组成部分，并且与发育异常和细胞衰老相关。 ROS 和 MT 功能在健康个体认知中的作用相对尚不充分研究。在这项研究中，我们表征了过表达线粒体过氧化氢酶 (MCAT) 的 5-6 个月大小鼠的行为和认知表现。 MCAT 小鼠在水迷宫和情境恐惧调节中显示出海马依赖性空间学习和记忆的增强，并在高架零迷宫中减少了焦虑测量。 MCAT 小鼠所有大脑区域的过氧化氢酶活性均升高。氧化应激指标（谷胱甘肽、蛋白质羰基含量、脂质过氧化和 8-羟基鸟嘌呤）在各组之间没有显着差异。这些氧化应激标志物缺乏差异表明，本研究中观察到的差异可能是由于氧化还原信号的改变所致。即使 OS 水平没有改变，过氧化氢酶过度表达也可能足以增强认知并减少焦虑程度。
Oxidative stress (OS) and reactive oxygen species (ROS) play a modulatory role in synaptic plasticity and signaling pathways. Mitochondria (MT), a major source of ROS due to their involvement in energy metabolism, are important for brain function. MT-generated ROS are proposed to be responsible for a significant proportion of OS and are associated with developmental abnormalities and aspects of cellular aging. The role of ROS and MT function in cognition of healthy individuals is relatively understudied. In this study, we characterized behavioral and cognitive performance of 5–6 month mice overexpressing mitochondrial catalase (MCAT). MCAT mice showed enhancements in hippocampus-dependent spatial learning and memory in the water maze and contextual fear conditioning, and reduced measures of anxiety in the elevated zero maze. Catalase activity was elevated in MCAT mice in all brain regions examined. Measures of oxidative stress (glutathione, protein carbonyl content, lipid peroxidation, and 8-hydroxyguanine) did not significantly differ between the groups. The lack of differences in these markers of oxidative stress suggests that the differences observed in this study may be due to altered redox signaling. Catalase overexpression might be sufficient to enhance cognition and reduce measures of anxiety even in the absence of alteration in levels of OS.
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影响因子：
8.2
作者：
Choleris, E;Thomas, AW;Prato, FS
通讯作者：
Prato, FS
影响因子：
56.9
作者：
Ishikawa, Kaori;Takenaga, Keizo;Hayashi, Jun-Ichi
通讯作者：
Hayashi, Jun-Ichi
DOI：
10.1111/j.1532-5415.1972.tb00787.x
发表时间：
1972-01-01
影响因子：
6.3
作者：
HARMAN, D
通讯作者：
HARMAN, D
影响因子：
3.5
作者：
FANSELOW, MS
通讯作者：
FANSELOW, MS
DOI：
10.1111/j.1749-6632.2008.03960.x
发表时间：
2009-01-01
期刊：
NEUROIMMUNOMODULATION: FROM FUNDAMENTAL BIOLOGY TO THERAPY
影响因子：
--
作者：
Gimsa, Ulrike;Kanitz, Ellen;Ibrahim, Saleh M.
通讯作者：
Ibrahim, Saleh M.