Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics.
Effects of Decreased Occlusal Loading during Growth on the Mandibular Bone Characteristics.
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DOI：
10.1371/journal.pone.0129290
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Langenbach GE
中科院分区：
文献类型：
--
作者：
Hichijo N;Tanaka E;Kawai N;van Ruijven LJ;Langenbach GE
骨量和矿化在很大程度上受负荷的影响。本研究的目的是评估整个下颌骨在生长过程中对负荷降低的反应。假设肌肉负荷降低将导致废用期间观察到的骨变化，即骨量丢失。将10只21日龄Wistar系雄性大鼠分为两组（每组n=5），分别饲喂硬饲料或软饲料11周。采用微型计算机断层扫描技术对骨矿化、骨体积、骨体积分数（BV/TV）进行研究并进行形态学分析。下颌骨矿化模式非常一致，显示出较低的矿化程度，在支比在体。在软饮食组中，磨牙以下的矿化与硬饮食组相比显著增加（p<0.05）。软食组髁状突和咬肌附着区的骨体积、BV/TV均低于对照组（p<0.05）。形态学分析显示，软食组大鼠下颌升支生长受到抑制（p<0.05）。软质饮食减少负荷会导致下颌骨发生显著变化。然而，这些变化是非常具体的区域，可能取决于在当地加载制度的改变。结果表明，生长过程中的肌肉活动是非常重要的骨质量和形态。
Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass. Ten 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05). Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
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影响因子：
1.9
作者：
Bresin, A;Kiliaridis, S;Strid, KG
通讯作者：
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影响因子：
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通讯作者：
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