Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation.
Low-level Pb and cardiovascular responses to acute stress in children: the role of cardiac autonomic regulation.
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DOI：
10.1016/j.ntt.2010.10.001
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发表时间：
2011-03
影响因子：
2.9
通讯作者：
Parsons, Patrick J.
中科院分区：
文献类型：
--
作者：
Gump, Brooks B.;MacKenzie, James A.;Bendinskas, Kestutis;Morgan, Robert;Dumas, Amy K.;Palmer, Christopher D.;Parsons, Patrick J.
许多研究表明，铅暴露会增加人类患心血管疾病的风险。作为这种影响的一个潜在机制，我们最近报道了幼儿期铅水平和心血管对急性应激反应之间的显着关联。当前的研究考虑了当前铅水平与新儿童队列中心血管对压力反应的自主神经系统激活模式之间的关联。我们评估了9-11岁儿童（N = 140）的血铅水平以及心血管对急性应激的反应。还评估了交感神经激活（用射血前期测量）和副交感神经激活（用高频心率变异性测量）。在一个血铅水平非常低的样本中（M = 1.01 μg/dL），我们发现血铅的增加与急性应激时交感神经和副交感神经激活的共抑制有关。此外，增加铅水平与血流动力学应激反应模式的典型共抑制-显着更大的血管阻力和减少每搏输出量和心输出量。血铅水平与儿童急性心理应激时自主神经和心血管功能失调有关。此外，这些影响是显着的铅水平被认为是非常低的，特别是远低于10微克/分升的疾病控制和预防中心定义的血铅水平升高。在铅水平下，许多美国儿童的自主神经功能失调可能会产生广泛的公共卫生后果。
A number of studies suggest that Pb exposure increases cardiovascular disease risk in humans. As a potential mechanism for this effect, we recently reported a significant association between early childhood Pb levels and cardiovascular response to acute stress. The current study considers the association between current Pb levels and the autonomic nervous system activation pattern underlying the cardiovascular response to stress in a new cohort of children. We assessed blood Pb levels as well as cardiovascular responses to acute stress in 9–11 year old children (N = 140). Sympathetic activation (measured with pre-ejection period) and parasympathetic activation (measured with high frequency heart rate variability) were also assessed. In a sample with very low levels of blood Pb (M = 1.01 μg/dL), we found that increasing blood Pb was associated with coinhibition of sympathetic and parasympathetic activation in response to acute stress. In addition, increasing Pb levels were associated with the hemodynamic stress response pattern typical of coinhibition – significantly greater vascular resistance and reduced stroke volume and cardiac output. Blood Pb levels were associated with significant autonomic and cardiovascular dysregulation in response to acute psychological stress in children. Moreover, these effects were significant at Pb levels considered to be very low and notably well below the 10 μg/dL the Centers for Disease Control and Prevention definition of an elevated blood Pb level. The potential for autonomic dysregulation at levels of Pb typical for many US children would suggest potentially broad public health ramifications.
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DOI：
10.1111/j.1540-5834.2009.00501.x
发表时间：
2009
影响因子：
9.5
作者：
El-Sheikh M;Kouros CD;Erath S;Cummings EM;Keller P;Staton L
通讯作者：
Staton L
影响因子：
10.4
作者：
Baos, Raquel;Blas, Julio;Bortolotti, Gary R;Marchant, Tracy A;Hiraldo, Fernando
通讯作者：
Hiraldo, Fernando
影响因子：
158.5
作者：
BATUMAN, V;LANDY, E;WEDEEN, RP
通讯作者：
WEDEEN, RP
影响因子：
5.3
作者：
Balslev, D;Christensen, LOD;Miall, RC
通讯作者：
Miall, RC
影响因子：
3.7
作者：
Berntson, Gary G.;Norman, Greg J.;Cacioppo, John T.
通讯作者：
Cacioppo, John T.