Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA.
Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA.
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SS-OCT/OCTA 评估成人屈光不正的脉络膜血管和脉络膜毛细血管血流灌注
DOI：
10.1167/iovs.62.1.8
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发表时间：
2021-01-04
影响因子：
4.4
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Wu H;Zhang G;Shen M;Xu R;Wang P;Guan Z;Xie Z;Jin Z;Chen S;Mao X;Qu J;Zhou X
目的 探讨屈光不正患者的脉络膜血管分布和脉络膜毛细血管血流灌注与近视严重程度的关系。方法测量了 34 名屈光不正的年轻人的屈光不正、眼轴（AL）和其他生物特征参数。通过扫源光学相干断层扫描 (SS-OCT) 垂直和水平 B 扫描确定黄斑脉络膜厚度 (ChT) 和脉络膜血管分布，包括总脉络膜面积 (TCA)、管腔面积 (LA)、基质面积 (SA) 和脉络膜血管分布指数 (CVI)。从正面 SS-OCT 血管造影获得脉络膜毛细血管血流空隙的百分比 (FV%)。结果 近视程度较高的眼睛的等效球面屈光度 (SER) 为 –3.35 ± 1.25 屈光度，近视程度较低的眼睛为 –1.25 ± 1.17 屈光度 (P < 0.001)。 SER的眼间差异与AL的眼间差异高度相关（P<0.001）。在垂直和水平扫描中，近视程度较高的眼睛的黄斑 ChT、TCA、LA 和 SA 均小于近视程度较低的眼睛（所有 P < 0.001）。重要的是，近视程度越高，垂直和水平扫描的 CVI 越小，FV% 越大（P < 0.05）。在垂直扫描中，CVI 的眼间差异与 SER、AL 和 ChT 的眼间差异相关（均 P < 0.05）。 FV% 的眼间差异与 SER、AL 以及垂直和水平 ChT 的差异相关（均 P < 0.05）。结论 成人屈光不正的近视眼的脉络膜血管分布和脉络膜毛细血管血流灌注较低。这些变化与近视的严重程度和脉络膜变薄相关，表明人类近视时脉络膜血流受到干扰。
Purpose To explore the association of choroidal vascularity and choriocapillaris blood perfusion with myopic severity in anisomyopes. Methods Refractive error, axial length (AL), and other biometric parameters were measured in 34 anisomyopic young adults. Macular choroidal thickness (ChT) and choroidal vascularity, including total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI), were determined from swept-source optical coherence tomography (SS-OCT) vertical and horizontal B-scans. The percentage of choriocapillaris flow voids (FV%) was obtained from en face SS-OCT-angiography. Results The spherical equivalent refraction (SER) was –3.35 ± 1.25 diopters in the more myopic eyes and –1.25 ± 1.17 diopters in the less myopic eyes (P < 0.001). The interocular difference in SER was highly correlated with that in AL (P < 0.001). The macular ChT, TCA, LA, and SA were smaller in the more myopic eyes than in the less myopic eyes in both vertical and horizontal scans (all P < 0.001). Importantly, the CVIs in vertical and horizontal scans were smaller and the FV% was greater in the more myopic eyes (P < 0.05). In vertical scans, the interocular difference in CVIs was correlated with that in the SER, AL, and ChT (all P < 0.05). The interocular difference in FV% was correlated with that in SER, AL, and vertical and horizontal ChTs (all P < 0.05). Conclusions Choroidal vascularity and choriocapillaris blood perfusion were lower in the more myopic eyes of anisomyopic adults. These changes were correlated with the severity of myopia and choroidal thinning, indicating that choroidal blood flow is disturbed in human myopia.
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影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
17.8
作者：
Nickla, Debora L.;Wallman, Josh
通讯作者：
Wallman, Josh
影响因子：
4.4
作者：
Al-Sheikh, Mayss;Phasukkijwatana, Nopasak;Sarraf, David
通讯作者：
Sarraf, David
扫频光学相干断层扫描测量不同屈光状态儿童的脉络膜和视网膜厚度
影响因子：
4.2
作者：
Jin, Peiyao;Zou, Haidong;He, Xiangui
通讯作者：
He, Xiangui
影响因子：
17.8
作者：
Ferrara, Daniela;Waheed, Nadia K.;Duker, Jay S.
通讯作者：
Duker, Jay S.