Allatotropin: an ancestral myotropic neuropeptide involved in feeding.
Allatotropin: an ancestral myotropic neuropeptide involved in feeding.
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腺体蛋白：一种参与喂养的祖先肌体性神经肽。
DOI：
10.1371/journal.pone.0077520
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ronderos JR
中科院分区：
文献类型：
--
作者：
Alzugaray ME;Adami ML;Diambra LA;Hernandez-Martinez S;Damborenea C;Noriega FG;Ronderos JR
细胞-细胞相互作用是组织和器官的基本原理，使它们能够执行综合功能并在空间和时间上组织自己。由神经元和上皮细胞分泌的肽分子在细胞-细胞相互作用中发挥基本作用，充当局部神经调质、神经激素以及内分泌和旁分泌信使。Allatotropin（AT）是一种神经肽，最初被描述为保幼激素合成的调节剂，在昆虫和其他生物中起着神经、内分泌和肌肉活性的多种作用。使用AT-抗体和AT-Qdot结合物的免疫组织化学的组合被用来识别免疫反应性神经细胞含有的肽和上皮肌肉细胞AT在水螅plagiodesmica的目标。使用AT和AT-抗体的生理测定显示，虽然AT刺激的hypostome的挤压在饥饿的水螅体中的剂量-反应方式，hypostome的活动在挑战与食物的水螅体被阻断治疗与不同剂量的AT-抗体。AT抗体免疫标记的神经细胞在柄，足盘，触角和hypostome。AT-Qdot缀合物识别相同组织中的上皮-肌肉细胞，表明这两种细胞群体之间存在解剖和功能关系。生理分析表明，AT样肽是促进食物摄取。免疫化学、生理学和生物信息学证据支持AT是参与与膳食摄取和消化相关的肌调节活动的祖先神经肽。
Cell-cell interactions are a basic principle for the organization of tissues and organs allowing them to perform integrated functions and to organize themselves spatially and temporally. Peptidic molecules secreted by neurons and epithelial cells play fundamental roles in cell-cell interactions, acting as local neuromodulators, neurohormones, as well as endocrine and paracrine messengers. Allatotropin (AT) is a neuropeptide originally described as a regulator of Juvenile Hormone synthesis, which plays multiple neural, endocrine and myoactive roles in insects and other organisms. A combination of immunohistochemistry using AT-antibodies and AT-Qdot nanocrystal conjugates was used to identify immunoreactive nerve cells containing the peptide and epithelial-muscular cells targeted by AT in Hydra plagiodesmica. Physiological assays using AT and AT- antibodies revealed that while AT stimulated the extrusion of the hypostome in a dose-response fashion in starved hydroids, the activity of hypostome in hydroids challenged with food was blocked by treatments with different doses of AT-antibodies. AT antibodies immunolabeled nerve cells in the stalk, pedal disc, tentacles and hypostome. AT-Qdot conjugates recognized epithelial-muscular cell in the same tissues, suggesting the existence of anatomical and functional relationships between these two cell populations. Physiological assays indicated that the AT-like peptide is facilitating food ingestion. Immunochemical, physiological and bioinformatics evidence advocates that AT is an ancestral neuropeptide involved in myoregulatory activities associated with meal ingestion and digestion.
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DOI：
10.1073/pnas.89.22.10915
发表时间：
1992-11-15
影响因子：
11.1
作者：
HENIKOFF, S;HENIKOFF, JG
通讯作者：
HENIKOFF, JG
影响因子：
3.6
作者：
Hernández-Martínez, S;Li, YP;Noriega, FG
通讯作者：
Noriega, FG
影响因子：
56.9
作者：
KATAOKA, H;TOSCHI, A;KRAMER, SJ
通讯作者：
KRAMER, SJ
影响因子：
3.8
作者：
Horodyski, Frank M.;Verlinden, Heleen;Broeck, Jozef Vanden
通讯作者：
Broeck, Jozef Vanden
影响因子：
3
作者：
Elekonich, MM;Horodyski, FM
通讯作者：
Horodyski, FM