Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acids.
Considerations regarding neuropsychiatric nutritional requirements for intakes of omega-3 highly unsaturated fatty acids.
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DOI：
10.1016/j.plefa.2009.06.005
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Davis JM
中科院分区：
文献类型：
--
作者：
Hibbeln JR;Davis JM
Adverse neurodevelopmental and neuropsychiatric outcomes have been established as signs of nutrient deficiencies and may be applicable to insufficient dietary intakes of omega-3 long chain fatty acids (n-3 LCFAs). Consider if statistical definitions for Daily Reference Intakes can be applied to n-3 LCFAs intakes during pregnancy for maternal and neurodevelopmental deficiencies. Data was prospectively collected from women during pregnancy and children up to age 8 y participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Statistical analyses took social and lifestyle factors into account. During pregnancy, n-3 LCFA intakes from seafood that putatively meet statistical definitions of an Estimated Average Requirement ranged from 0.05 –0.06 en % (111–139 mg/d/2,000 Cal) for suboptimal fine motor control at 42 m and 0.065-0.08 en% (114–181 mg/d/2,000 Cal) for suboptimal verbal IQ at age 8 y and 0.18–0.22 en% (389–486 mg/d/2,000 Cal) for maternal depression at 32 w. Intakes of n-3 ranging from 0.2–0.41 en% (445 – 917 mg/d/2,000 Cal) prevented both increased risk of maternal depression and adverse neurodevelopmental outcomes for children among 97.5% of the population. No upper limit for safety was found. During pregnancy, a n-3 LCFA intake of 0.40 en% (900 mg/d/2,000 Cal) from seafood is likely to meet the nutritional requirements for 97.5 % of the mothers and children of this population. These considerations do not constitute DRI’s for docosahexaenoic acid and n-3 LCFAs, but may contribute to their formulation.
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