The role of the thalamus and hippocampus in episodic memory performance in patients with multiple sclerosis.
The role of the thalamus and hippocampus in episodic memory performance in patients with multiple sclerosis.
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DOI：
10.1177/1352458518760716
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发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
Phillips MD
中科院分区：
文献类型：
--
作者：
Koenig KA;Rao SM;Lowe MJ;Lin J;Sakaie KE;Stone L;Bermel RA;Trapp BD;Phillips MD
情景记忆丧失是多发性硬化症（MS）患者最常见的认知症状之一，但这种症状的病理生理机制尚不清楚。海马和丘脑都有牵连的情景记忆和MS患者的区域萎缩。在这项工作中，我们使用功能磁共振成像（fMRI）在口头情景记忆任务，病变负荷，和体积的海马和丘脑的措施，以评估口头和视觉空间情景记忆的相对贡献。32例MS患者和16例健康对照者的功能激活、病变负荷和体积测量用于情景记忆功能的预测分析。在调整疾病持续时间后，海马体积显著预测视觉空间情景记忆任务的即时回忆表现（p < 0.003）。左丘脑体积对同一任务的延迟回忆有显著预测作用（p < 0.003）。对于这两种记忆测量，在编码过程中丘脑的功能激活比容量测量更具预测性（p < 0.002）。我们的研究结果表明，功能激活可能是有用的MS患者的情景记忆丧失的预测措施。
Episodic memory loss is one of the most common cognitive symptoms in patients with multiple sclerosis (MS), but the pathophysiology of this symptom remains unclear. Both the hippocampus and thalamus have been implicated in episodic memory and show regional atrophy in patients with MS. In this work, we used functional magnetic resonance imaging (fMRI) during a verbal episodic memory task, lesion load, and- volumetric measures of the hippocampus and thalamus to assess the relative contributions to verbal and visual spatial episodic memory. Functional activation, lesion load, and volumetric measures from 32 patients with MS and 16 healthy controls were used in a predictive analysis of episodic memory function. After adjusting for disease duration, immediate recall performance on a visual spatial episodic memory task was significantly predicted by hippocampal volume (p < 0.003). Delayed recall on the same task was significantly predicted by volume of the left thalamus (p < 0.003). For both memory measures, functional activation of the thalamus during encoding was more predictive than that of volume measures (p < 0.002). Our results suggest that functional activation may be useful as a predictive measure of episodic memory loss in patients with MS.
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DOI：
10.1073/pnas.1110024108
发表时间：
2011-11-22
影响因子：
11.1
作者：
Hawellek, David J.;Hipp, Joerg F.;Engel, Andreas K.
通讯作者：
Engel, Andreas K.
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
影响因子：
3.7
作者：
Dineen, Robert A.;Bradshaw, Christopher M.;Auer, Dorothee P.
通讯作者：
Auer, Dorothee P.
影响因子：
2.5
作者：
Johnson, MD;Ojemann, GA
通讯作者：
Ojemann, GA
影响因子：
5.8
作者：
Benedict, Ralph H. B.;Hulst, Hanneke E.;Zivadinov, Robert
通讯作者：
Zivadinov, Robert