A neutral model of transcriptome evolution.
A neutral model of transcriptome evolution.
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DOI：
10.1371/journal.pbio.0020132
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发表时间：
2004-05
期刊：
影响因子：
9.8
通讯作者：
Pääbo S
中科院分区：
文献类型：
--
作者：
Khaitovich P;Weiss G;Lachmann M;Hellmann I;Enard W;Muetzel B;Wirkner U;Ansorge W;Pääbo S
微阵列技术允许鉴定物种内和物种之间的大量表达差异。虽然环境和生理刺激是明确负责的许多基因的表达水平的变化，它是不知道是否大多数的基因表达的变化，在物种之间和物种内的各种组织之间的进化过程中固定是由达尔文选择或随机过程。我们发现：（1）物种间的表达差异随时间近似线性累积;（2）物种内个体间的基因表达变异与物种间的表达差异正相关;（3）物种间的表达差异率在完整基因和表达的假基因之间没有显著差异;（4）由于一个物种的大脑区域在进化过程中出现，这些区域之间的表达差异随着时间的推移近似线性地积累。这些结果表明，物种之间观察到的大多数表达差异是选择性中性或接近中性的，可能很少或没有功能意义。因此，通过选择固定的物种之间的基因表达差异的鉴定应该基于假设功能中性的零假设。此外，基于表达差异的分子钟可能用于推断组织的进化历史。对灵长类物种之间基因表达差异的分析表明，它们中的大多数是选择性中性的，可能很少或没有功能性后果。
Microarray technologies allow the identification of large numbers of expression differences within and between species. Although environmental and physiological stimuli are clearly responsible for changes in the expression levels of many genes, it is not known whether the majority of changes of gene expression fixed during evolution between species and between various tissues within a species are caused by Darwinian selection or by stochastic processes. We find the following: (1) expression differences between species accumulate approximately linearly with time; (2) gene expression variation among individuals within a species correlates positively with expression divergence between species; (3) rates of expression divergence between species do not differ significantly between intact genes and expressed pseudogenes; (4) expression differences between brain regions within a species have accumulated approximately linearly with time since these regions emerged during evolution. These results suggest that the majority of expression differences observed between species are selectively neutral or nearly neutral and likely to be of little or no functional significance. Therefore, the identification of gene expression differences between species fixed by selection should be based on null hypotheses assuming functional neutrality. Furthermore, it may be possible to apply a molecular clock based on expression differences to infer the evolutionary history of tissues. Analysis of differences in gene expression between primate species suggests that the majority of them are selectively neutral and likely to have little or no functional consequences
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DOI：
10.1098/rspb.1979.0086
发表时间：
1979-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GOULD, SJ;LEWONTIN, RC
通讯作者：
LEWONTIN, RC
DOI：
10.1073/pnas.041605498
发表时间：
2001-02-27
影响因子：
11.1
作者：
Miki, R;Kadota, K;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
56.9
作者：
Ranz, JM;Castillo-Davis, CI;Hartl, DL
通讯作者：
Hartl, DL
影响因子：
30.8
作者：
Oleksiak, MF;Churchill, GA;Crawford, DL
通讯作者：
Crawford, DL
影响因子：
30.8
作者：
Rifkin, SA;Kim, J;White, KP
通讯作者：
White, KP