Mood lability among offspring of parents with bipolar disorder and community controls.
Mood lability among offspring of parents with bipolar disorder and community controls.
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DOI：
10.1111/bdi.12060
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发表时间：
2013-05
影响因子：
5.4
通讯作者：
Kupfer DJ
中科院分区：
文献类型：
--
作者：
Birmaher B;Goldstein BI;Axelson DA;Monk K;Hickey MB;Fan J;Iyengar S;Ha W;Diler RS;Goldstein T;Brent D;Ladouceur CD;Sakolsky D;Kupfer DJ
双相情感障碍（BP）的早期诊断对改善预后至关重要.据报道，BP患者的情绪不稳定性增加。然而，情绪不稳定在精神疾病中普遍存在，可能是严重精神病理学的标志物，而不是BP特有的。为了澄清这一问题，本研究探讨了情绪不稳定的患病率及其组成部分，在后代的BP父母和后代的社区控制父母通过匹兹堡双极后代研究招募。38名BP父母的41名学龄BP后代，174名BP父母的257名健康或非BP后代，以及117名对照父母的192名后代完成了一项评估青年情绪不稳定的量表，即，儿童情绪不稳定量表（CALS）对父母CALS和部分儿童CALS的因素分析显示易怒、躁狂和焦虑/抑郁因素，其中大部分方差由易怒因素解释。在调整混杂因素（例如，父母和后代的非BP精神病理学），BP父母的BP后代表现出最高的父母和孩子的总分和因子得分，其次是BP父母的非BP后代，然后是对照组的后代。情绪不稳定的整体和躁狂样，焦虑/抑郁，特别是易怒的症状可能是一个前驱表型的BP父母与BP的后代。前瞻性研究是必要的，以澄清这些症状是否会预测BP和/或其他精神病理学的发展。如果得到证实，这些症状可能成为BP发展之前治疗和生物学研究的目标。
Early identification of bipolar disorder (BP) symptomatology is crucial for improving the prognosis of this illness. Increased mood lability has been reported in BP. However, mood lability is ubiquitous across psychiatric disorders and may be a marker of severe psychopathology and not specific to BP. To clarify this issue, this study examined the prevalence of mood lability and its components in offspring of BP parents and offspring of community control parents recruited through the Pittsburgh Bipolar Offspring Study. Forty-one school-age BP offspring of 38 BP parents, 257 healthy or non-BP offspring of 174 BP parents, and 192 offspring of 117 control parents completed a scale that was developed to evaluate mood lability in youth, i.e., the Children’s Affective Lability Scale (CALS). A factor analysis of the parental CALS, and in part the child CALS, revealed Irritability, Mania, and Anxiety/Depression factors, with most of the variance explained by the Irritability factor. After adjusting for confounding factors (e.g., parental and offspring non-BP psychopathology), BP offspring of BP parents showed the highest parental and child total and factor scores, followed by the non-BP offspring of BP parents, and then the offspring of the controls. Mood lability overall and mania-like, anxious/depressed, and particularly irritability symptoms may be a prodromal phenotype of BP among offspring of parents with BP. Prospective studies are warranted to clarify whether these symptoms will predict the development of BP and/or other psychopathology. If confirmed, these symptoms may become a target of treatment and biological studies before BP develops.
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DOI：
10.1097/00004583-200010000-00011
发表时间：
2000-10-01
影响因子：
13.3
作者：
Egeland, JA;Hostetter, AM;Sussex, JN
通讯作者：
Sussex, JN
影响因子：
6.6
作者：
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通讯作者：
KASHANI, JH
影响因子：
5.3
作者：
Biederman, Joseph;Petty, Carter R.;Wozniak, Janet
通讯作者：
Wozniak, Janet
影响因子：
5.4
作者：
Farchione, Tiffany R.;Birmaher, Boris;Brent, David
通讯作者：
Brent, David
DOI：
10.1097/00004583-199707000-00020
发表时间：
1997-07-01
影响因子：
13.3
作者：
Chilcoat, HD;Breslau, N
通讯作者：
Breslau, N