Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight.
Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight.
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DOI：
10.3389/fpsyt.2023.1276300
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发表时间：
2023
影响因子：
4.7
通讯作者：
Yanovski, Jack A.
中科院分区：
文献类型：
--
作者：
Byrne, Meghan E.;Tanofsky-Kraff, Marian;Liuzzi, Lucrezia;Holroyd, Tom;Parker, Megan N.;Bloomer, Bess F.;Nugent, Allison;Brady, Sheila M.;Yang, Shanna B.;Turner, Sara A.;Pine, Daniel S.;Yanovski, Jack A.
饮食失控（LOC）是暴食症的一个关键特征，可能将注意力偏差（AB）与高度显着的人际刺激联系起来。目前的试点研究使用脑磁图（MEG）来探索有或没有吃LOC的青春期女孩AB对社会威胁线索的神经特征。超重或肥胖（BMI > 85%）的女孩（12-17 岁）在 MEG 期间完成情感点探针 AB 任务的 AB 测量，并捕获对愤怒或快乐（与中性）面部线索的诱发神经反应。实验室测试膳食范例测量了能量摄入和常量营养素消耗模式。女孩（N = 34；法师 = 15.5 ± 1.5 岁；BMI-z = 1.7 ± 0.4）在注意力部署期间，与左背外侧前额叶皮层（与执行控制和调节过程有关的神经区域）中性面部线索相比，对愤怒面部表情的诱发反应迟钝（p < 0.01）。与没有吃LOC的女孩（N = 21）相比，吃LOC的女孩（N = 13）在注意力部署过程中视觉皮层对愤怒面孔的诱发反应更强（p < 0.001）。视觉和认知控制 ROI 的趋势表明，LOC 饮食的女孩与测试膳食摄入模式存在相互作用 (ps = 0.01)。这些发现表明，超重或肥胖的女孩可能无法适应性地参与与高阶执行过程有关的神经区域。这种困难可能与不受抑制的饮食模式有关，从而导致体重过度增加。
Loss-of-control (LOC) eating, a key feature of binge-eating disorder, may relate attentional bias (AB) to highly salient interpersonal stimuli. The current pilot study used magnetoencephalography (MEG) to explore neural features of AB to socially threatening cues in adolescent girls with and without LOC-eating. Girls (12–17 years old) with overweight or obesity (BMI >85th percentile) completed an AB measure on an affective dot-probe AB task during MEG and evoked neural responses to angry or happy (vs. neutral) face cues were captured. A laboratory test meal paradigm measured energy intake and macronutrient consumption patterns. Girls (N = 34; Mage = 15.5 ± 1.5 years; BMI-z = 1.7 ± 0.4) showed a blunted evoked response to the presentation of angry face compared with neutral face cues in the left dorsolateral prefrontal cortex, a neural region implicated in executive control and regulation processes, during attention deployment (p < 0.01). Compared with those without LOC-eating (N = 21), girls with LOC-eating (N = 13) demonstrated a stronger evoked response to angry faces in the visual cortex during attention deployment (p < 0.001). Visual and cognitive control ROIs had trends suggesting interaction with test meal intake patterns among girls with LOC-eating (ps = 0.01). These findings suggest that girls with overweight or obesity may fail to adaptively engage neural regions implicated in higher-order executive processes. This difficulty may relate to disinhibited eating patterns that could lead to excess weight gain.
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影响因子：
5.7
作者：
Jarcho JM;Tanofsky-Kraff M;Nelson EE;Engel SG;Vannucci A;Field SE;Romer AL;Hannallah L;Brady SM;Demidowich AP;Shomaker LB;Courville AB;Pine DS;Yanovski JA
通讯作者：
Yanovski JA
影响因子：
4.3
作者：
Gramfort A;Luessi M;Larson E;Engemann DA;Strohmeier D;Brodbeck C;Goj R;Jas M;Brooks T;Parkkonen L;Hämäläinen M
通讯作者：
Hämäläinen M
影响因子：
5.9
作者：
Yokum S;Stice E
通讯作者：
Stice E
影响因子：
3.8
作者：
Arias Ramos, N.;Calvo Sanchez, M. D.;Marques-Sanchez, P.
通讯作者：
Marques-Sanchez, P.
影响因子：
12.8
作者：
Cisler JM;Koster EH
通讯作者：
Koster EH