Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena.
Transient Inactivation of the Medial Prefrontal Cortex and Ventral Hippocampus Impairs Active Place Avoidance Retrieval on a Rotating Arena.
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DOI：
10.3389/fncir.2021.634533
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发表时间：
2021
影响因子：
3.5
通讯作者：
Svoboda J
中科院分区：
文献类型：
--
作者：
Cernotova D;Stuchlik A;Svoboda J
众所周知，内侧前额叶皮层（mPFC）和腹侧海马体（vHPC）之间的交流对各种认知和行为功能至关重要。然而，这些结构在空间协调中的确切作用仍有待澄清。在这里，我们试图确定成年雄性Long-Evans大鼠mPFC和vHPC参与先前学习的主动位置回避任务的空间检索，使用单侧和双侧局部muscimol失活的组合。此外，我们通过执行同侧和对侧联合灭活来测试vHPC-mPFC通路的作用。我们的研究结果表明，不仅双侧结构失活，而且双侧结构失活对空间记忆检索也有影响，而单侧结构失活对空间记忆检索没有任何影响。值得注意的是，无论是对侧失活还是同侧失活，联合组注射muscimol都会产生类似的缺陷。这些发现证实了这些结构在空间认知中的重要性，并强调了vHPC-mPFC通路完整功能的重要性。
It is well known that communication between the medial prefrontal cortex (mPFC) and the ventral hippocampus (vHPC) is critical for various cognitive and behavioral functions. However, the exact role of these structures in spatial coordination remains to be clarified. Here we sought to determine the involvement of the mPFC and the vHPC in the spatial retrieval of a previously learned active place avoidance task in adult male Long-Evans rats, using a combination of unilateral and bilateral local muscimol inactivations. Moreover, we tested the role of the vHPC-mPFC pathway by performing combined ipsilateral and contralateral inactivations. Our results showed not only bilateral inactivations of either structure, but also the combined inactivations impaired the retrieval of spatial memory, whereas unilateral one-structure inactivations did not yield any effect. Remarkably, muscimol injections in combined groups exerted similar deficits, regardless of whether the inactivations were contralateral or ipsilateral. These findings confirm the importance of these structures in spatial cognition and emphasize the importance of the intact functioning of the vHPC-mPFC pathway.
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影响因子：
3.1
作者：
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通讯作者：
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