Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.
Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry.
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DOI：
10.1371/journal.pone.0098768
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kitazono T
中科院分区：
文献类型：
--
作者：
Kaizu S;Kishimoto H;Iwase M;Fujii H;Ohkuma T;Ide H;Jodai T;Kikuchi Y;Idewaki Y;Hirakawa Y;Nakamura U;Kitazono T
在亚洲2型糖尿病患者中，休闲时间体力活动（LTPA）对糖尿病和心血管危险因素的影响尚未完全了解，这些患者通常不肥胖。我们研究了日本2型糖尿病患者中LTPA与糖尿病和心血管危险因素之间的关系。根据LTPA将4，870例年龄≥20岁的日本2型糖尿病患者分为8组。我们在一项横断面研究中调查了体力活动（PA）的量和强度水平与血糖控制、胰岛素敏感性、心血管危险因素和低度全身炎症之间的关系。LTPA与体重指数（BMI）、腰围、血红蛋白A1c（HbA1c）、空腹血糖、胰岛素抵抗的稳态模型评估、甘油三酯、高密度脂蛋白胆固醇、高敏C反应蛋白和代谢综合征的患病率呈剂量依赖性相关，但与血压、低密度脂蛋白胆固醇或脂联素无关。降低HbA1c所需的PA量大于改善心血管危险因素所需的PA量。在对年龄、性别、糖尿病病程、当前吸烟、当前饮酒、能量摄入、心血管疾病、抑郁症状和糖尿病治疗进行多变量校正后，非肥胖受试者的LTPA与HbA1c呈负相关，但在肥胖受试者中不相关。经过多变量校正和进一步校正（包括BMI）后，高强度LTPA而非低强度LTPA与HbA1c相关。在日本2型糖尿病患者中，LTPA与更好的血糖控制和某些心血管危险因素的改善呈剂量依赖性相关。此外，增加高强度LTPA可能适合血糖控制。
The effects of leisure-time physical activity (LTPA) on glycemia and cardiovascular risk factors are not fully understood in Asian type 2 diabetic patients, who are typically non-obese. We studied associations between LTPA and glycemia and cardiovascular risk factors in Japanese type 2 diabetic patients. A total of 4,870 Japanese type 2 diabetic patients aged ≥20 years were divided into eight groups according to their LTPA. We investigated associations between the amount and intensity levels of physical activity (PA) and glycemic control, insulin sensitivity, cardiovascular risk factors, and low-grade systemic inflammation in a cross-sectional study. LTPA was dose-dependently associated with body mass index (BMI), waist circumference, hemoglobin A1c (HbA1c), fasting plasma glucose, homeostasis model assessment of insulin resistance, triglyceride, high density lipoprotein cholesterol, high sensitivity C-reactive protein, and prevalence of metabolic syndrome, but not with blood pressure, low density lipoprotein cholesterol or adiponectin. The amount of PA required to lower HbA1c was greater than that required to improve cardiovascular risk factors. LTPA was inversely associated with HbA1c in non-obese participants but not in obese participants after multivariate adjustments for age, sex, duration of diabetes, current smoking, current drinking, energy intake, cardiovascular diseases, depressive symptoms, and treatment of diabetes. Higher-intensity LTPA, not lower-intensity LTPA was associated with HbA1c after multivariate adjustments with further adjustment including BMI. LTPA was dose-dependently associated with better glycemic control and amelioration of some cardiovascular risk factors in Japanese type 2 diabetic patients. In addition, increased higher-intensity LTPA may be appropriate for glycemic control.
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影响因子：
16.2
作者：
Chudyk A;Petrella RJ
通讯作者：
Petrella RJ
影响因子：
16.2
作者：
Kodama S;Tanaka S;Heianza Y;Fujihara K;Horikawa C;Shimano H;Saito K;Yamada N;Ohashi Y;Sone H
通讯作者：
Sone H
影响因子：
3.3
作者：
Iijima, Katsuya;Iimuro, Satoshi;Ito, Hideki
通讯作者：
Ito, Hideki
影响因子：
3.7
作者：
Balducci S;Zanuso S;Cardelli P;Salvi L;Bazuro A;Pugliese L;Maccora C;Iacobini C;Conti FG;Nicolucci A;Pugliese G;Italian Diabetes Exercise Study (IDES) Investigators
通讯作者：
Italian Diabetes Exercise Study (IDES) Investigators
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.