Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers.
Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers.
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DOI：
10.1016/j.biomaterials.2013.02.040
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发表时间：
2013-05
期刊：
影响因子：
14
通讯作者：
Yang, Jian
中科院分区：
文献类型：
--
作者：
Zhang, Yi;Tran, Richard T.;Qattan, Ibrahim S.;Tsai, Yi-Ting;Tang, Liping;Liu, Chao;Yang, Jian
组织工程和药物输送领域呼唤新的测量工具、非侵入性实时分析和设计方法，以应对下一波创新浪潮。基于我们在开发无共轭有机染料或量子点的本征可生物降解光致发光聚合物(BPLP)方面的最新进展，本文开发了一种新型的氨基甲酸酯掺杂生物可降解光致发光聚合物(UBPLP)，它可能成为响应上述创新呼吁的新工具。UBPLPs是从BPLPs中继承而来的，在体外表现出强烈的固有光致发光和良好的细胞相容性。交联型UBPLP具有柔软、弹性好、力学性能强的特点，拉伸强度高达49.41±6.17 Mpa，断裂伸长率为334.87±26.31%。多孔三相CuBPLP血管支架的破裂压力为769.33±70.88 mm Hg，缝线保持强度为1.79±0.11N，但通过纳米沉淀法也得到了平均尺寸为103 nm的发光纳米颗粒。UBPLP纳米粒具有较高的载药率(91.84%)和缓释效果(最长可达120h)。由于量子产率高达38.65%，三相支架和纳米颗粒溶液均可在体内无创检测。UBPLP代表了荧光生物材料设计的一项创新，并可能在组织工程和药物输送领域提供巨大的潜力，在这些领域，生物成像受到越来越多的关注。
The field of tissue engineering and drug delivery calls for new measurement tools, non-invasive real-time assays, and design methods for the next wave of innovations. Based on our recent progress in developing intrinsically biodegradable photoluminescent polymers (BPLPs) without conjugating organic dyes or quantum dots, in this paper, we developed a new type urethane-doped biodegradable photoluminescent polymers (UBPLPs) that could potentially serve as a new tool to respond the above call for innovations. Inherited from BPLPs, UBPLPs demonstrated strong inherent photoluminescence and excellent cytocompatibility in vitro. Crosslinked UBPLPs (CUBPLPs) showed soft, elastic, but strong mechanical properties with a tensile strength as high as 49.41±6.17 MPa and a corresponding elongation at break of 334.87±26.31%. Porous triphasic CUBPLP vascular scaffolds showed a burst pressure of 769.33±70.88 mmHg and a suture retention strength of 1.79±0.11 N. Stable but photoluminescent nanoparticles with average size of 103 nm were also obtained by nanoprecipitation. High loading efficiency (91.84%) and sustained release of 5-fluorouracil (up to 120 h) were achieved from UBPLP nanoparticles. With a quantum yield as high as 38.65%, both triphasic scaffold and nanoparticle solutions could be non-invasively detected in vivo. UBPLPs represent an innovation in fluorescent biomaterial design and may offer great potential in advancing the field of tissue engineering and drug delivery where bioimaging has gained increasing interest.
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影响因子：
29.4
作者：
Yang, J;Webb, AR;Ameer, GA
通讯作者：
Ameer, GA
影响因子：
46.9
作者：
Jaiswal, JK;Mattoussi, H;Simon, SM
通讯作者：
Simon, SM
DOI：
10.4028/www.scientific.net/kem.288-289.59
发表时间：
2005-01-01
期刊：
ASBM6: ADVANCED BIOMATERIALS VI
影响因子：
--
作者：
Tateishi, T;Chen, G
通讯作者：
Chen, G
影响因子：
41.2
作者：
通讯作者：
--
影响因子：
3.9
作者：
Dey, Jagannath;Tran, Richard T.;Yang, Jian
通讯作者：
Yang, Jian