Mandibular distraction osteogenesis assisted by cell-based tissue engineering: a systematic review.

Mandibular distraction osteogenesis assisted by cell-based tissue engineering: a systematic review.
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DOI:
10.1111/ocr.12087
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发表时间:
2015-04
影响因子:
3.1
通讯作者:
Sun Z
Sun Z
中科院分区:
医学3区
文献类型:
--
作者:
Tee BC;Sun Z

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综述近年来间充质干细胞(MSC)移植辅助下颌骨牵张成骨(MDO)研究的进展和局限性。遵循系统评价和荟萃分析的首选报告项目 (PRISMA) 指南,对 PubMed、SCOPUS 和 Cochrane 电子数据库从建立到 2014 年 8 月进行了系统的搜索和筛选。搜索术语包括:“牵引成骨”、“下颌骨或下颌或颌”和“细胞”,没有任何其他限制。从 227 篇发表的文章中选出了 19 项符合资格标准的研究,并用于定性综合。其中 15 项研究使用小动物模型(大鼠或兔子),而另外 4 项研究使用大型动物模型(狗、猪或羊)。这些研究中,MDO方案、细胞移植时间、途径和数量以及结果评估方法存在较大差异。此外,所有研究都存在一定的偏差。尽管如此,大多数研究发现MSC移植增强了MDO骨再生。动物研究的证据表明,间充质干细胞移植可能会增强 MDO,但与动物模型、MDO 方案和细胞移植相关的许多问题仍有待研究。
To review the advances and limitations of recent investigations on mandibular distraction osteogenesis (MDO) assisted by mesenchymal stem cell (MSC) transplantation. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, the PubMed, SCOPUS, and Cochrane electronic databases were systematically searched and screened from their inception through August 2014. Searching terms included: ‘distraction osteogenesis’, ‘mandible or mandibular or jaw’, and ‘cells’, without any other limitations. Nineteen studies meeting the eligibility criteria were selected from 227 published articles and used for qualitative synthesis. Fifteen of the studies used small animal models (rats or rabbits), while the other 4 used large animal models (dogs, pigs or sheep). Among these studies, large variations exist in MDO protocol, cell transplantation time, route and quantity, as well as methodology of outcome assessment. Additionally, all studies had certain biases. Nevertheless, the majority of studies found that MSC transplantation enhanced MDO bone regeneration. Evidence from animal studies indicate that MDO may be enhanced by mesenchymal stem cell transplantation, but many questions related to animal models, MDO protocols, and cell transplantation remain to be investigated.
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