Do Maternal Microbes Shape Newborn Oral Microbes?
Do Maternal Microbes Shape Newborn Oral Microbes?
复制标题
母体微生物会影响新生儿口腔微生物吗？
DOI：
10.1007/s12088-020-00901-7
复制
发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Jianye Zhou
中科院分区：
文献类型：
--
作者：
Shengrong Wu;Fei Yu;Liya Ma;Youhong Zhao;Xin Zheng;Xiaodong Li;Zhiqiang Li;Xiangyi He;Jianye Zhou
强有力的证据表明，新生儿口腔微生物群的早期组成对口腔健康或免疫系统的出生后发育起着重要作用。然而，母体微生物组与初始新生儿微生物组之间的关系仍不清楚。本研究选取25名孕妇及其新生儿，分别采集孕妇口腔、羊水、胎盘及新生儿口腔标本。使用Illumina MiSeq平台进行16S rRNA的高通量测序，以分析母体和新生儿口腔之间的微生物群落结构的相关性。结果表明，四组中共有OTU的数量高达635个。PCoA结果表明，四个类群的微生物群落结构具有一定的相似性。共有OTU的优势菌属与人类口腔微生物一致，包括链球菌属、梭杆菌属和普雷沃菌属。结果表明，通过羊水和胎盘，母亲和新生儿口腔微生物组之间可能存在相关性。
Strong evidence suggests that the early composition of the oral microbiota of neonates plays an important role for the postnatal development of the oral health or immune system. However, the relationship between the maternal microbiome and the initial neonatal microbiome remains unclear. In this study, 25 pregnant women and their neonates were recruited, and the samples were collected from the maternal oral cavity, amniotic fluid, placenta and neonatal oral cavity. High-throughput sequencing of 16S rRNA was performed using the Illumina MiSeq platform to analyze the correlation with microbial community structure between the maternal and the neonatal oral cavity. The results indicated that the number of shared OTUs was up to 635 in four groups. The PCoA showed that there were certain similarities in the microbial community structure of the four groups. The dominant bacterial genera of the shared OTUs were consistent with human oral microbes, includingStreptococcus, FusobacteriumandPrevotella. The results showed that there might be a correlation between the maternal and neonatal oral microbiome, through the amniotic fluid and placenta.
登录
查看更多内容
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
2.6
作者：
Jimenez, Esther;Marin, Maria L.;Rodriguez, Juan M.
通讯作者：
Rodriguez, Juan M.
DOI：
10.1186/s40748-015-0007-4
发表时间：
2015
期刊：
Maternal health, neonatology and perinatology
影响因子：
--
作者：
Neu J
通讯作者：
Neu J
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
--
作者：
B. Sampaio-Maia;Filipa Monteiro-Silva
通讯作者：
B. Sampaio-Maia;Filipa Monteiro-Silva