Earthworms dilong: ancient, inexpensive, noncontroversial models may help clarify approaches to integrated medicine emphasizing neuroimmune systems.
Earthworms dilong: ancient, inexpensive, noncontroversial models may help clarify approaches to integrated medicine emphasizing neuroimmune systems.
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DOI：
10.1155/2012/164152
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Paoletti MG
中科院分区：
文献类型：
--
作者：
Cooper EL;Balamurugan M;Huang CY;Tsao CR;Heredia J;Tommaseo-Ponzetta M;Paoletti MG
蚯蚓为古代文化提供了食物和药物来源。阿育吠陀、传统中医 (TCM) 以及日本、越南和韩国的实践首先将蚯蚓作为食物来源。逐步培育一种具有潜在有益治疗特性的方法，通过生物勘探和循证研究进行了新的努力，通过严格的调查了解蚯蚓是否被用作食物和/或潜在医药产品的来源的作用机制。通过对蚯蚓先天免疫系统的广泛分析，我们对蚯蚓的研究是偶然发现的。他们的免疫系统充满了白细胞和体液产物，可以发挥可靠的健康益处。它们在先天免疫进化方面的新兴功能早已被其在土壤保持中众所周知的生态作用所取代。蚯蚓作为廉价、无争议的动物模型（没有伦理问题）不是疾病的载体，不含有威胁人类的寄生虫，也不是令人讨厌的害虫。通过认识到它们在生态、环境和生物医学方面的众多作用，并通过廉价且更全面的研究证实，我们将更加了解它们未被发现的有益特性。
Earthworms have provided ancient cultures with food and sources of medicinal cures. Ayurveda, traditional Chinese medicine (TCM), and practices in Japan, Vietnam, and Korea have focused first on earthworms as sources of food. Gradually fostering an approach to potential beneficial healing properties, there are renewed efforts through bioprospecting and evidence-based research to understand by means of rigorous investigations the mechanisms of action whether earthworms are used as food and/or as sources of potential medicinal products. Focusing on earthworms grew by serendipity from an extensive analysis of the earthworm's innate immune system. Their immune systems are replete with leukocytes and humoral products that exert credible health benefits. Their emerging functions with respect to evolution of innate immunity have long been superseded by their well-known ecological role in soil conservation. Earthworms as inexpensive, noncontroversial animal models (without ethical concerns) are not vectors of disease do not harbor parasites that threaten humans nor are they annoying pests. By recognizing their numerous ecological, environmental, and biomedical roles, substantiated by inexpensive and more comprehensive investigations, we will become more aware of their undiscovered beneficial properties.
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DOI：
10.1093/ecam/neh002
发表时间：
2004-06-01
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Cooper EL
通讯作者：
Cooper EL
DOI：
10.1093/ecam/neh094
发表时间：
2005-06
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Cooper EL
通讯作者：
Cooper EL
DOI：
10.1093/ecam/nep216
发表时间：
2011
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chang YM;Kuo WH;Lai TY;Shih YT;Tsai FJ;Tsai CH;Shu WT;Chen YY;Chen YS;Kuo WW;Huang CY
通讯作者：
Huang CY
影响因子：
5.1
作者：
Balamurugan, Mariappan;Parthasarathi, Kasi;Cooper, Edwin L.
通讯作者：
Cooper, Edwin L.
DOI：
10.1155/2012/918956
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Franchi GC Jr;Moraes CS;Toreti VC;Daugsch A;Nowill AE;Park YK
通讯作者：
Park YK