In vitro and in vivo evaluation of SU-8 biocompatibility.
In vitro and in vivo evaluation of SU-8 biocompatibility.
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DOI：
10.1016/j.msec.2013.07.001
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Gimi B
中科院分区：
文献类型：
--
作者：
Nemani KV;Moodie KL;Brennick JB;Su A;Gimi B
SU-8负性光致抗蚀剂是一种高拉伸强度聚合物，已用于许多生物医学应用，包括细胞封装和神经元探针。在化学上，SU-8包括环氧基单体和锑盐，后者是细胞毒性的潜在来源。我们报告SU-8生物相容性的体外和体内评价的基础上，从各种溶剂的沥滤物，在不同的温度和pH值，并在皮下植入SU-8基板在小鼠。MTT细胞活力试验未显示出沥滤物的任何细胞毒性效应。SU-8的溶血活性与FDA批准的植入材料（如硅橡胶、Buna-S和医用钢）相当。小鼠体内组织相容性研究表明，皮下SU-8植入物的免疫应答减弱。
SU-8 negative photoresist is a high tensile strength polymer that has been used for a number of biomedical applications that include cell encapsulation and neuronal probes. Chemically, SU-8 comprises, among other components, an epoxy based monomer and antimony salts, the latter being a potential source of cytotoxicity. We report on the in vitro and in vivo evaluation of SU-8 biocompatibility based on leachates from various solvents, at varying temperature and pH, and upon subcutaneous implantation of SU-8 substrates in mice. MTT cell viability assay did not exhibit any cytotoxic effects from the leachates. The hemolytic activity of SU-8 is comparable to that of FDA approved implant materials such as silicone elastomer, Buna-S and medical steel. In vivo histocompatibility study in mice indicates a muted immune response to subcutaneous SU-8 implants.
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影响因子：
9.7
作者：
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通讯作者：
Ben-Jonathan, Nira
DOI：
10.1007/s10856-008-3471-9
发表时间：
2009-12-01
影响因子：
3.7
作者：
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通讯作者：
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通讯作者：
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DOI：
10.1016/j.msec.2009.01.002
发表时间：
2009-06-01
期刊：
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
影响因子：
--
作者：
Henkelman, Sandra;Rakhorst, Gerhard;van Oeveren, Willem
通讯作者：
van Oeveren, Willem
影响因子：
4.3
作者：
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通讯作者：
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