Insulin-sensitive adiposity is associated with a relatively lower risk of diabetes than insulin-resistant adiposity: the Bogalusa Heart Study.
Insulin-sensitive adiposity is associated with a relatively lower risk of diabetes than insulin-resistant adiposity: the Bogalusa Heart Study.
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与胰岛素抵抗性肥胖相比，胰岛素敏感性肥胖与糖尿病的风险相对较低：Bogalusa 心脏研究
DOI：
10.1007/s12020-016-0948-z
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发表时间：
2016-10
期刊：
影响因子：
3.7
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Zhang T;Li Y;Zhang H;Sun D;Li S;Fernandez C;Harville E;Bazzano L;He J;Chen W
肥胖和胰岛素抵抗都与2型糖尿病（T2DM）密切相关。然而，目前尚不清楚肥胖在T2DM发展中的作用是否依赖于胰岛素抵抗。本研究旨在评估胰岛素敏感性肥胖与T2DM风险相对较低相关的假设，以及中年黑人和白人成年人胰岛素抵抗改变肥胖与T2DM的关联。纵向研究队列包括1588名年龄在18-44岁的中年血糖正常的黑人和白人成年人，平均随访16年。基线时超重/肥胖被定义为BMI≥25，并使用胰岛素抵抗稳态模型评估（HOMA）来测量胰岛素抵抗。比较胰岛素敏感组和胰岛素抵抗组的糖尿病前期和2型糖尿病发生率。胰岛素抵抗型肥胖组的糖尿病前期和T2DM发生率均高于胰岛素敏感型肥胖组（糖尿病前期11.5% vs. 7.5%, p = 0.023; T2DM 16.7% vs. 2.7%, p < 0.001）。在多变量logistic分析中，校正了基线年龄、种族、性别、随访年数和吸烟，基线胰岛素抵抗性肥胖与糖尿病前期（比值比，OR = 2.07, p = 0.046）和T2DM （OR = 8.19, p < 0.001）相关。黑人和白人之间的ORs没有差异。BMI与糖尿病前期和T2DM相关的or值在基线HOMA增加的四分位数中显著增加（糖尿病前期趋势p = 0.032， T2DM趋势p <0.001）。以回归系数（β）测量的基线BMI随随访血糖升高的斜率，胰岛素抵抗组明显大于胰岛素敏感组（β = 0.86 vs. 0.38，斜率差异p = 0.009）。这些发现表明，胰岛素抵抗放大了肥胖与糖尿病的关联，并强调了在年轻人中预防肥胖和胰岛素抵抗的重要性。
Obesity and insulin resistance are both closely associated with type 2 diabetes mellitus (T2DM). It is, however, not clear whether the role of obesity in the development of T2DM is dependent on insulin resistance. This study aims to assess the hypothesis that insulin-sensitive adiposity is associated with a relatively lower risk of T2DM than insulin-resistant adiposity, and the adiposity–T2DM association is modified by insulin resistance in middle-aged black and white adults. The longitudinal study cohort consisted of 1588 middle-aged normoglycemic black and white adults aged 18–44 years at baseline who were followed for 16 years on average. Overweight/obesity at baseline was defined as BMI ≥25, and insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA). The prevalence of incident pre-diabetes and T2DM was compared between the insulin-sensitive and insulin-resistant adiposity groups. The prevalence of both incident pre-diabetes and T2DM was higher in the insulin-resistant adiposity than in the insulin-sensitive adiposity group (11.5 vs. 7.5 %, p = 0.023 for pre-diabetes; 16.7 vs. 2.7 %, p < 0.001 for T2DM). In multivariable logistic analyses, adjusted for baseline age, race, sex, follow-up years, and smoking, baseline insulin-resistant obesity was associated with incident pre-diabetes (odds ratio, OR = 2.07, p = 0.046) and T2DM (OR = 8.19, p < 0.001). ORs did not differ between blacks and whites. The ORs for the association of BMI with pre-diabetes and T2DM significantly increased across increasing quartiles of baseline HOMA (p for trend = 0.032 for pre-diabetes and <0.001 for T2DM). Slopes of increasing follow-up glucose with baseline BMI, measured as regression coefficients (β), were significantly greater in insulin-resistant than in insulin-sensitive individuals (β = 0.86 vs. 0.38, p = 0.009 for difference in slopes). These findings suggest that insulin resistance amplifies the obesity–diabetes association and underscore the importance of preventing both adiposity and insulin resistance in young adults.
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影响因子：
16.2
作者：
Nguyen QM;Srinivasan SR;Xu JH;Chen W;Kieltyka L;Berenson GS
通讯作者：
Berenson GS
影响因子：
5
作者：
Chen, Wei;Srinivasan, Sathanur R.;Berenson, Gerald S.
通讯作者：
Berenson, Gerald S.
DOI：
10.1001/archpediatrics.2009.268
发表时间：
2010-02-01
影响因子：
--
作者：
Nguyen, Quoc Manh;Srinivasan, Sathanur R.;Berenson, Gerald S.
通讯作者：
Berenson, Gerald S.
影响因子：
--
作者：
McLaughlin, Tracey;Abbasi, Fahim;Reaven, Gerald
通讯作者：
Reaven, Gerald
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.