Enhanced antibacterial properties of biocompatible titanium via electrochemically deposited Ag/TiO(2) nanotubes and chitosan-gelatin-Ag-ZnO complex coating.
Enhanced antibacterial properties of biocompatible titanium via electrochemically deposited Ag/TiO(2) nanotubes and chitosan-gelatin-Ag-ZnO complex coating.
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通过电化学沉积Ag/TiO2纳米管和壳聚糖-明胶-Ag-ZnO复合涂层增强生物相容性钛的抗菌性能
DOI：
10.1039/c8ra07682k
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发表时间：
2019-01-30
期刊：
影响因子：
3.9
通讯作者：
Zhong, Cheng
中科院分区：
文献类型：
--
作者：
Yin, Linling;Fu, Zhenxuan;Li, Yuan;Liu, Bin;Lin, Zongjian;Lu, Jiayu;Chen, Xu;Han, Xiaopeng;Deng, Yida;Hu, Wenbin;Zou, Derong;Zhong, Cheng
采用简单的三步电沉积工艺在纯钛表面制备了一种新型双层抗菌涂层。扫描电子显微镜(SEM)图像显示，涂层由掺杂银纳米粒子的二氧化钛纳米管(TNTs/Ag)内层和壳聚糖-明胶/氧化锌-银纳米粒子混合物(CS-Gel-Ag-ZnO)组成。作为对比，我们还研究了TNTs、TNTs/Ag和TNTs/Ag+CS-Gel-Ag-ZnO包覆纯钛的成分、结构和抗菌性能。TNTs宽约100 nm，高240 nm~370 nm，大部分直径小于20 nm的银纳米颗粒(Ag NPs)成功地沉积在管内。CS-Gel-Ag-ZnO膜层连续均匀。同时考察了其对浮游细菌和附着细菌的抑菌活性。对金黄色葡萄球菌的琼脂扩散试验表明，TNTs/Ag+CS-Gel-Ag-ZnO涂层的抗菌能力得到了提高，其明显的抑菌区(Zoi)宽达14.5 mm。扫描电子显微镜下可见表面有死亡的贴壁细菌。对浮游金黄色葡萄球菌的抑菌率在24 h内高达99.2%。通过简单的三步电沉积工艺制备了一种新型复合抗菌涂层，其抗菌率高达99.2%。
A novel double-layered antibacterial coating was fabricated on pure titanium (Ti) via a simple three-step electrodeposition process. Scanning electronic microscopy (SEM) images show that the coating was constructed with the inner layer of TiO2 nanotubes doped with silver nanoparticles (TNTs/Ag) and the outer layer of chitosan–gelatin mixture with zinc oxide and silver nanoparticles (CS–Gel–Ag–ZnO). In comparison, we also investigated the composition, structure and antibacterial properties of pure Ti coated with TNTs, TNTs/Ag or TNTs/Ag + CS–Gel–Ag–ZnO, respectively. The TNTs was about 100 nm wide and 240 nm to 370 nm tall, and most Ag nanoparticles (Ag NPs) with diameter smaller than 20 nm were successfully deposited inside the tubes. The CS–Gel–Ag–ZnO layer was continuous and uniform. Antibacterial activity against planktonic and adherent bacteria were both investigated. Agar diffusion test against Staphylococcus aureus (S. aureus) shows improved antibacterial capacity of the TNTs/Ag + CS–Gel–Ag–ZnO coating, with a clear zone of inhibition (ZOI) up to 14.5 mm wide. Dead adherent bacteria were found on the surface by SEM. The antibacterial rate against planktonic S. aureus was as high as 99.2% over the 24 h incubation period. A novel complex antibacterial coating fabricated via a simple three-step electrodeposition process shows high antibacterial rate of 99.2%.
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影响因子：
11.2
作者：
Liu, Yangshuo;Kim, Hyung-Il
通讯作者：
Kim, Hyung-Il
影响因子：
19
作者：
Luo, Honglin;Xiong, Peixun;Xu, Yunhua
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影响因子：
3.9
作者：
Hunagund, Shirajahammad M.;Desai, Vani R.;Sidarai, Ashok H.
通讯作者：
Sidarai, Ashok H.
影响因子：
3.5
作者：
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通讯作者：
Yacaman, MJ
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11.2
作者：
Chen, SP;Wu, GZ;Zeng, HY
通讯作者：
Zeng, HY