Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex.
Enhancing memory performance with rTMS in healthy subjects and individuals with Mild Cognitive Impairment: the role of the right dorsolateral prefrontal cortex.
复制标题
DOI：
10.3389/fnhum.2012.00062
复制
发表时间：
2012
影响因子：
2.9
通讯作者：
Cipolotti L
中科院分区：
文献类型：
--
作者：
Turriziani P;Smirni D;Zappalà G;Mangano GR;Oliveri M;Cipolotti L
文献中一个有争议的问题是，在再认记忆提取过程中，背外侧前额叶皮质(DLPFC)辅助的执行控制过程在解剖和功能上的偏侧化程度。我们研究了100名健康对照组(HC)和8名轻度认知障碍(MCI)患者在提取时通过重复经颅磁刺激(RTMS)对左右DLPFC的短暂抑制和兴奋是否调节了识别记忆能力。在不同的实验中使用了面孔、建筑物和单词的识别记忆任务。RTMS-抑制右侧DLPFC增强HCS和MCIS的识别记忆。RTMS-HCS中相同区域的兴奋会降低记忆性能。抑制右侧DLPFC可以调节同侧和对侧大脑半球脑区网络的兴奋性，增强HCS的功能或恢复MCI的适应性平衡。
A debated question in the literature is the degree of anatomical and functional lateralization of the executive control processes sub-served by the dorsolateral prefrontal cortex (DLPFC) during recognition memory retrieval. We investigated if transient inhibition and excitation of the left and right DLPFC at retrieval by means of repetitive transcranial magnetic stimulation (rTMS) modulate recognition memory performance in 100 healthy controls (HCs) and in eight patients with Mild Cognitive Impairment (MCI). Recognition memory tasks of faces, buildings, and words were used in different experiments. rTMS-inhibition of the right DLPFC enhanced recognition memory in both HCs and MCIs. rTMS-excitation of the same region in HCs deteriorated memory performance. Inhibition of the right DLPFC could modulate the excitability of a network of brain regions, in the ipsilateral as well as in the contralateral hemisphere, enhancing function in HCs or restoring an adaptive equilibrium in MCI.
登录
查看更多内容
影响因子：
3.2
作者：
McDermott, KB;Buckner, RL;Sanders, AL
通讯作者：
Sanders, AL
影响因子：
3.3
作者：
Manenti, R.;Cotelli, M.;Miniussi, C.
通讯作者：
Miniussi, C.
影响因子：
3.7
作者：
Floel, A;Poeppel, D;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
5.3
作者：
Grady, CL;McIntosh, AR;Black, SE
通讯作者：
Black, SE
影响因子：
4.8
作者：
FOLSTEIN, MF;FOLSTEIN, SE;MCHUGH, PR
通讯作者：
MCHUGH, PR