Preoperative prognostic nutritional index is a powerful predictor of prognosis in patients with stage III ovarian cancer.
Preoperative prognostic nutritional index is a powerful predictor of prognosis in patients with stage III ovarian cancer.
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术前预后营养指数是III期卵巢癌患者预后的有力预测指标。
DOI：
10.1038/s41598-017-10328-8
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发表时间：
2017-08-25
影响因子：
4.6
通讯作者：
Ren Y
中科院分区：
文献类型：
--
作者：
Zhang W;Ye B;Liang W;Ren Y
许多已确定的炎症和营养相关因素已被研究作为各种癌症的潜在独立预后因素，包括c反应蛋白/白蛋白比（CAR）、淋巴细胞/单核细胞比（LMR）、改良格拉斯哥预后评分（mGPS）、体重指数（BMI）和预后营养指数（PNI）。本研究旨在评估这些因素在预测卵巢癌（OC）生存率和铂耐药方面的预后价值，特别是根据分期。Kaplan-Meier和多变量分析绘制生存曲线并确定独立预后因素。此外，通过比较PNI和癌抗原(CA)-125的预测能力，利用受试者工作特征曲线下面积（AUC）预测铂耐药和预后。在所有患者中，PNI下降与铂耐药、总生存期（OS）和无进展生存期（PFS）差显著相关。就肿瘤分期而言，PNI下降仅与III期OC的PFS和OS差显著相关。此外，在预测所有OC患者的死亡率和铂耐药方面，PNI的AUC值也明显高于CA-125，但在III期患者中则不然。总之，PNI降低是OC预后不良的有力预测因子，特别是对于III期病例。
Many established inflammation- and nutrition-related factors have been investigated as potential independent prognostic factors in various cancers, including the C-reactive protein/albumin ratio (CAR), lymphocyte/monocyte ratio (LMR), modified Glasgow prognostic score (mGPS), body mass index (BMI), and prognostic nutritional index (PNI). This study was performed to estimate the prognostic value of these factors in predicting survival and platinum resistance in ovarian cancer (OC), especially according to stage. Kaplan-Meier and multivariate analyses were performed to plot the survival curve and determine the independent prognostic factors. Additionally, the area under the receiver operating characteristic curve (AUC) was used to predict platinum resistance and prognosis by comparing the predictive ability of PNI and cancer antigen (CA)-125. In all patients, decreased PNI was significantly associated with platinum resistance and poor overall survival (OS) and progression-free survival (PFS). Regarding tumor stage, decreased PNI was significantly associated with poor PFS and OS only in stage III OC. Furthermore, the PNI also showed a significantly higher AUC value than CA-125 for predicting mortality and platinum resistance in all OC patients, but not in stage III patients. In conclusion, decreased PNI is a powerful predictor of a poor prognosis in OC, and especially for stage III cases.
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影响因子：
7.4
作者：
Milne K;Alexander C;Webb JR;Sun W;Dillon K;Kalloger SE;Gilks CB;Clarke B;Köbel M;Nelson BH
通讯作者：
Nelson BH
影响因子：
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2.6
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通讯作者：
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3.7
作者：
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通讯作者：
Nakajima, Yoshiyuki