Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation.
Primary sensory and motor cortex excitability are co-modulated in response to peripheral electrical nerve stimulation.
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DOI：
10.1371/journal.pone.0051298
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chipchase LS
中科院分区：
文献类型：
--
作者：
Schabrun SM;Ridding MC;Galea MP;Hodges PW;Chipchase LS
外周电刺激(PES)是临床上常见的一种诱发皮质运动兴奋性改变的方法；应用PES可诱发强直性运动收缩增加，而PES在运动阈值下(感觉)强度降低，皮质运动兴奋性降低。对皮质运动兴奋性的这些相反变化背后的机制的理解仍然难以捉摸。初级感觉皮质(S1)兴奋性的调节可能是PES患者皮质运动性兴奋性改变的基础。在这里，我们研究了当使用相同的刺激参数施加PES时，初级感觉(S1)和运动(M1)皮质兴奋性的变化是否遵循相同的时间-过程。采用经颅磁刺激(TMS)和体感诱发电位(SEPS)检测右侧拇短展肌(APB)PES前、后30min的皮质兴奋性和感觉皮质兴奋性。分别测试了两种PES模式：足以诱发强直性运动收缩(30-50赫兹；强运动强度)的PES和运动阈值以下强度(100赫兹)的PES。应用PES来诱导APB的强烈激活增加了N20-P25成分的大小，被认为反映了皮层水平的感觉处理，并增加了皮质运动的兴奋性。感觉强度的PES减小了P25-N33成分的大小，降低了皮质运动的兴奋性。在感觉和运动性PES后，皮层SEP成分的幅度变化与皮质运动兴奋性之间呈正相关。感觉性PES也增加了皮层下P14-N20 SEP成分。这些发现提供了证据，证明PES导致S1和M1兴奋性的共同调制，可能是由于S1和M1之间的皮质投射。这一机制可能支持皮层运动兴奋性的改变，以响应由PES产生的传入输入。
Peripheral electrical stimulation (PES) is a common clinical technique known to induce changes in corticomotor excitability; PES applied to induce a tetanic motor contraction increases, and PES at sub-motor threshold (sensory) intensities decreases, corticomotor excitability. Understanding of the mechanisms underlying these opposite changes in corticomotor excitability remains elusive. Modulation of primary sensory cortex (S1) excitability could underlie altered corticomotor excitability with PES. Here we examined whether changes in primary sensory (S1) and motor (M1) cortex excitability follow the same time-course when PES is applied using identical stimulus parameters. Corticomotor excitability was measured using transcranial magnetic stimulation (TMS) and sensory cortex excitability using somatosensory evoked potentials (SEPs) before and after 30 min of PES to right abductor pollicis brevis (APB). Two PES paradigms were tested in separate sessions; PES sufficient to induce a tetanic motor contraction (30–50 Hz; strong motor intensity) and PES at sub motor-threshold intensity (100 Hz). PES applied to induce strong activation of APB increased the size of the N20-P25 component, thought to reflect sensory processing at cortical level, and increased corticomotor excitability. PES at sensory intensity decreased the size of the P25-N33 component and reduced corticomotor excitability. A positive correlation was observed between the changes in amplitude of the cortical SEP components and corticomotor excitability following sensory and motor PES. Sensory PES also increased the sub-cortical P14-N20 SEP component. These findings provide evidence that PES results in co-modulation of S1 and M1 excitability, possibly due to cortico-cortical projections between S1 and M1. This mechanism may underpin changes in corticomotor excitability in response to afferent input generated by PES.
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影响因子：
2.5
作者：
KANEKO, T;CARIA, MA;ASANUMA, H
通讯作者：
ASANUMA, H
影响因子：
56.9
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MELZACK, R;WALL, PD
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WALL, PD
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Popovic, Milos R.;Kapadia, Naaz;McGillivray, Colleen
通讯作者：
McGillivray, Colleen
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DARIANSMITH, C;DARIANSMITH, I;CHEEMA, SS
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CHEEMA, SS
影响因子：
4.7
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Fernandez-del-Olmo, Miguel;Alvarez-Sauco, Maria;Rothwell, John C.
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Rothwell, John C.