Stachybotrys chartarum-A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance.

Stachybotrys chartarum-A Hidden Treasure: Secondary Metabolites, Bioactivities, and Biotechnological Relevance.
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DOI:
10.3390/jof8050504
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发表时间:
2022-05-12
期刊:
Journal of fungi (Basel, Switzerland)
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其他
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真菌被誉为生物代谢物的源泉,可用于生产新型治疗剂以及具有广泛生物技术和工业应用的酶。 Stachybotrys Chartarum(黑霉)(Stachybotriaceae)是一种产毒真菌,常见于潮湿环境中。这种真菌能够产生具有无与伦比的结构特征的各类生物代谢物,包括环孢菌素、cochliquinones、atranones、单端孢霉烯族化合物、dolabellanes、苯基螺环烷、氧杂蒽酮以及异吲哚啉和色烯衍生物。此外,它是各种酶的来源,这些酶可能具有不同的生物技术和工业相关性。当前的综述重点介绍了之前发布的 S. Chartarum 数据,包括其代谢物及其生物活性,以及​​从 1973 年到 2022 年初的工业和生物技术相关性。在这项工作中,列出了 215 种代谢物,引用了 138 篇参考文献。
Fungi are renowned as a fountainhead of bio-metabolites that could be employed for producing novel therapeutic agents, as well as enzymes with wide biotechnological and industrial applications. Stachybotrys chartarum (black mold) (Stachybotriaceae) is a toxigenic fungus that is commonly found in damp environments. This fungus has the capacity to produce various classes of bio-metabolites with unrivaled structural features, including cyclosporins, cochlioquinones, atranones, trichothecenes, dolabellanes, phenylspirodrimanes, xanthones, and isoindoline and chromene derivatives. Moreover, it is a source of various enzymes that could have variable biotechnological and industrial relevance. The current review highlights the formerly published data on S. chartarum, including its metabolites and their bioactivities, as well as industrial and biotechnological relevance dated from 1973 to the beginning of 2022. In this work, 215 metabolites have been listed and 138 references have been cited.
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