pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers.
pH in exhaled breath condensate and nasal lavage as a biomarker of air pollution-related inflammation in street traffic-controllers and office-workers.
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DOI：
10.6061/clinics/2013(12)03
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Nakagawa NK
中科院分区：
文献类型：
--
作者：
Lima TM;Kazama CM;Koczulla AR;Hiemstra PS;Macchione M;Fernandes AL;Santos Ude P;Bueno-Garcia ML;Zanetta DM;André CD;Saldiva PH;Nakagawa NK
利用低成本、简单的方法来评估与空气污染相关的气道和肺部炎症生物标志物。对总共 87 名担任街道交通管制员或办公室工作人员的男性、不吸烟、健康受试者进行了检查，以确定呼出气体中的一氧化碳，并测量鼻腔灌洗液和呼出气体冷凝物中的 pH 值。空气污染暴露通过颗粒物浓度来测量，数据从固定监测站获得（研究前连续5天每天工作8小时）。交通管制员呼出的一氧化碳是办公室工作人员的两倍。上班族呼出气冷凝液的平均pH值为8.12，鼻腔冲洗液的平均pH值为7.99；这些值在交通控制器中较低（分别为 7.80 和 7.30）。两组的两种底物中的细胞因子浓度相似，然而，与呼出的呼吸冷凝液相比，鼻腔灌洗液中的 IL-1β 和 IL-8 升高。与上班族相比，交通管制员工作场所的颗粒物浓度更高。鼻腔灌洗液和呼出气体冷凝物的 pH 值是重要、稳定、易于测量且可重复的生物标志物，可用于监测职业空气污染暴露。此外，与办公室工作人员相比，交通管制员在其职业活动中发生气道和肺部炎症的风险更高。
To utilize low-cost and simple methods to assess airway and lung inflammation biomarkers related to air pollution. A total of 87 male, non-smoking, healthy subjects working as street traffic-controllers or office-workers were examined to determine carbon monoxide in exhaled breath and to measure the pH in nasal lavage fluid and exhaled breath condensate. Air pollution exposure was measured by particulate matter concentration, and data were obtained from fixed monitoring stations (8-h work intervals per day, during the 5 consecutive days prior to the study). Exhaled carbon monoxide was two-fold greater in traffic-controllers than in office-workers. The mean pH values were 8.12 in exhaled breath condensate and 7.99 in nasal lavage fluid in office-workers; these values were lower in traffic-controllers (7.80 and 7.30, respectively). Both groups presented similar cytokines concentrations in both substrates, however, IL-1β and IL-8 were elevated in nasal lavage fluid compared with exhaled breath condensate. The particulate matter concentration was greater at the workplace of traffic-controllers compared with that of office-workers. The pH values of nasal lavage fluid and exhaled breath condensate are important, robust, easy to measure and reproducible biomarkers that can be used to monitor occupational exposure to air pollution. Additionally, traffic-controllers are at an increased risk of airway and lung inflammation during their occupational activities compared with office-workers.
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