Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
Association of tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.
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DOI：
10.1016/j.ajog.2010.06.005
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发表时间：
2010-11
影响因子：
9.8
通讯作者：
Zhong G
中科院分区：
文献类型：
--
作者：
Rodgers AK;Wang J;Zhang Y;Holden A;Berryhill B;Budrys NM;Schenken RS;Zhong G
该研究的目的是评估输卵管性不孕（TFI）、不孕对照（IFC）和生育对照（FC）患者抗沙眼衣原体热休克蛋白（HSP）的抗体。热休克蛋白帮助生物体在高温等腐蚀性环境中生存。21例TFI、15例IFC和29例FC患者在腹腔镜输卵管评估后入组。比较各组沙眼原体抗体滴度和14种衣原体热休克蛋白抗体滴度。TFI患者抗沙眼原体抗体水平明显升高，特异性识别衣原体HSP60和酪蛋白溶解蛋白酶（Clp） P，这是atp依赖性Clp蛋白酶复合物的一个亚基，参与异常蛋白的降解。除了在TFI患者中证实了针对沙眼原体和HSP60的高滴度抗体外，我们还发现了TFI与抗clpp抗体的新联系。这些发现可能为开发TFI的无创筛查试验和构建亚基抗沙眼原体疫苗提供有用的信息。
The objective of the study was to assess antibodies against Chlamydia trachomatis heat shock proteins (HSP) in patients with tubal factor infertility (TFI), infertility controls (IFC), and fertile controls (FC). HSPs assist organisms in surviving caustic environments such as heat. Twenty-one TFI, 15 IFC, and 29 FC patients were enrolled after laparoscopic tubal assessment. The titers of antibodies against C trachomatis organisms and 14 chlamydial HSPs were compared among the 3 groups. TFI patients developed significantly higher levels of antibodies against C trachomatis and specifically recognizing chlamydial HSP60 and caseinolytic protease (Clp) P, a subunit of the ATP-dependent Clp protease complex involved in the degradation of abnormal proteins. In addition to confirming high titers of antibodies against C trachomatis organisms and HSP60 in TFI patients, we identified a novel link of TFI with anti-ClpP antibodies. These findings may provide useful information for developing a noninvasive screening test for TFI and constructing subunit anti-C trachomatis vaccines.
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影响因子：
4.2
作者：
Luo J;Liu G;Zhong Y;Jia T;Liu K;Chen D;Zhong G
通讯作者：
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影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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