Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution.

Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution.
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DOI:
10.1016/j.tim.2014.08.001
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发表时间:
2014-10
影响因子:
15.9
通讯作者:
Memish ZA
Memish ZA
中科院分区:
生物学1区
文献类型:
--
作者:
Al-Tawfiq JA;Memish ZA

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中东呼吸综合征冠状病毒继续引起散发病例,并在医疗保健环境中扩大病例。骆驼被认为是中间宿主。需要采取适当的感染控制措施,以防止医院爆发。中东呼吸综合征冠状病毒(MERS-CoV)于2012年首次被描述,随后报告了许多病例,其病死率低于初始病例。人类可以在其社区内受到感染,然后在医疗保健环境中扩大传播。病例之间的接触调查显示,家庭成员和医护人员之间的传播量不同。到目前为止,在持续监测下,流行的病毒株保持相似,没有基因变化。在这里,我们讨论了MERS冠状病毒感染的传播模式,系统进化和发病机制。
MERS-CoV continues to cause sporadic cases with amplification of cases in the healthcare setting. Camels have been linked as an intermediate host. Proper infection control measures are needed to prevent nosocomial outbreaks. The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV infection.
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