Facile Microfluidic Fabrication of Biocompatible Hydrogel Microspheres in a Novel Microfluidic Device.
Facile Microfluidic Fabrication of Biocompatible Hydrogel Microspheres in a Novel Microfluidic Device.
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DOI：
10.3390/molecules27134013
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发表时间：
2022-06-22
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聚（乙二醇）二丙烯酸酯（PEGDA）微凝胶具有可调的大小和孔隙率发现作为细胞外基质模拟物的组织工程支架，生物传感器和药物载体的应用。单分散的PEGDA微凝胶通过模块化液滴微流体使用具有49-99重量%的PEGDA、1重量%的Darocur 2959和0-50重量%的水的分散相，而连续相是溶解在硅油中的3.5重量%的基于硅酮的表面活性剂来生产。在75 mW/cm 2的紫外光强度下，纯PEGDA液滴在60 s内完全固化。具有较高含水量的液滴需要更多的固化时间。由于氧抑制，聚合在液滴中心开始并向边缘推进，导致暂时的固体核/液体壳形态，通过跟踪液滴内荧光乳胶纳米颗粒的布朗运动来证实。对于纯PEGDA液滴，聚合期间的体积收缩率为1-4%，对于含有10-40重量%水的液滴，体积收缩率为20-32%。在去离子水中溶胀后，颗粒体积增加了36-50%。随着分散相含水量的增加，粒子的表面光滑度和球形度降低。通过改变分散相中的水含量从10重量%至40重量%，溶胀颗粒的孔隙率被控制在29.7%至41.6%。
Poly(ethylene glycol) diacrylate (PEGDA) microgels with tuneable size and porosity find applications as extracellular matrix mimics for tissue-engineering scaffolds, biosensors, and drug carriers. Monodispersed PEGDA microgels were produced by modular droplet microfluidics using the dispersed phase with 49–99 wt% PEGDA, 1 wt% Darocur 2959, and 0–50 wt% water, while the continuous phase was 3.5 wt% silicone-based surfactant dissolved in silicone oil. Pure PEGDA droplets were fully cured within 60 s at the UV light intensity of 75 mW/cm2. The droplets with higher water content required more time for curing. Due to oxygen inhibition, the polymerisation started in the droplet centre and advanced towards the edge, leading to a temporary solid core/liquid shell morphology, confirmed by tracking the Brownian motion of fluorescent latex nanoparticles within a droplet. A volumetric shrinkage during polymerisation was 1–4% for pure PEGDA droplets and 20–32% for the droplets containing 10–40 wt% water. The particle volume increased by 36–50% after swelling in deionised water. The surface smoothness and sphericity of the particles decreased with increasing water content in the dispersed phase. The porosity of swollen particles was controlled from 29.7% to 41.6% by changing the water content in the dispersed phase from 10 wt% to 40 wt%.
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影响因子：
6
作者：
Le Goff GC;Srinivas RL;Hill WA;Doyle PS
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Doyle PS
影响因子：
29.4
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3.9
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Jensen, Klavs F.
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影响因子：
3.4
作者：
Acosta-Cuevas JM;González-García J;García-Ramírez M;Pérez-Luna VH;Cisneros-López EO;González-Nuñez R;González-Reynoso O
通讯作者：
González-Reynoso O