Bronchomammary axis in the immune response to respiratory syncytial virus.
Bronchomammary axis in the immune response to respiratory syncytial virus.
复制标题
支气管乳腺轴对呼吸道合胞病毒的免疫反应。
DOI：
10.1016/s0022-3476(81)80447-7
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Ogra,PL
中科院分区：
文献类型：
--
作者：
Fishaut,M;Murphy,D;Neifert,M;McIntosh,K;Ogra,PL
在几个月的时间里，对26名哺乳母亲的哺乳产品进行了连续检查，以确定是否存在或出现针对呼吸道合胞病毒的抗体。在初乳或牛奶中很少发现抗生命的IgM和IgG。75%(18/24)的初乳标本中检出RSV特异性IgA，40%(6/15)和59%(4/7)的3个月和6个月乳样中仍含有RSV特异性IgA抗体。后者的增加被认为是当病毒存在于社区时，暴露于病毒的个人的增加。有记录表明，有两名母亲感染了这种病毒。两者在血清和鼻咽分泌物中均有特异性的免疫球蛋白G、免疫球蛋白M和免疫球蛋白A抗体反应，但在牛奶中的反应仅限于免疫球蛋白A。这些数据证实，哺乳产品中存在针对特定呼吸道病原体的抗体，其特定活性主要为IgA类，牛奶中的增强反应仅属于IgA类。由于RSV似乎只在呼吸道中复制，因此在乳腺中观察到的病毒特异性抗体活性可能来自于支气管肺淋巴组织。
The products of lactation from 26 nursing mothers were sequentially examined over several months for the presence or appearance of antibodies directed against respiratory syncytial virus. Antivital IgM and IgG were rarely identified in either colostrum or milk. RSV-specific IgA was found in 75% (18/24) of specimens of colostrum; 40% (6/15) and 59% (4/7) of milk samples obtained at three and six months still contained specific IgA antibody. The latter increase was felt to represent boosting of exposed individuals when the virus was present in the community. Infection with the virus was documented in two mothers. Both had specific IgG, IgM, and IgA antibody responses in serum and nasopharyngeal secretions, but response in milk was limited to IgA. These data confirm that antibody to a specific respiratory tract pathogen is present in the products of lactation, that the specific activity is mainly of the IgA class, and that booster responses in milk are exclusively of the IgA class. Since RSV appears to replicate only in the respiratory tract, it is suggested that viral specific antibody activity observed in the mammary gland may be derived from the bronchopulmonary lymphoid tissue.
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人乳免疫球蛋白的新知识
DOI：
--
发表时间：
1978
期刊：
Acta Paediatrica Scandinavica
影响因子：
--
作者：
L. Hanson;S. Ahlstedt;B. Carlsson;S. ;B. Kaijser;B. Lindblad;Akerlund As;Edén Cs
通讯作者：
Edén Cs
影响因子：
64.8
作者：
GOLDBLUM, RM;AHLSTEDT, S;SOHLAKERLUND, A
通讯作者：
SOHLAKERLUND, A
支气管和胃刺激后远程刺激分泌型 IgA 抗体。
影响因子：
--
作者：
P. C. Montgomery;K. M. Connelly;J. Cohn;C. A. Skandera
通讯作者：
C. A. Skandera
母乳喂养可以保护印度婴儿免受感染。
影响因子：
14.6
作者：
J. Ellestad;P. Coodin;L. Dilling;J. Haworth
通讯作者：
J. Haworth
口服免疫后产生特异性抗体的浆细胞的器官和同种型分布：广义分泌免疫系统的证据。
影响因子：
4.4
作者：
P. Weisz;M. Roux;M. Mcwilliams;J. M. Phillips;M. Lamm
通讯作者：
M. Lamm