Stimulation of human monocyte oxidative burst and related cytotoxicity by tumor-promoting and non-tumor-promoting diterpene esters, indole alkaloids and polyacetate-type agents.
Stimulation of human monocyte oxidative burst and related cytotoxicity by tumor-promoting and non-tumor-promoting diterpene esters, indole alkaloids and polyacetate-type agents.
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促肿瘤和非促肿瘤二萜酯、吲哚生物碱和聚乙酸酯类药物刺激人单核细胞氧化爆发和相关细胞毒性。
DOI：
10.1002/ijc.2910360409
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发表时间：
1985
影响因子：
6.4
通讯作者：
Lavie,G
中科院分区：
文献类型：
--
作者：
Keisari,Y;Geva,I;Flescher,E;Goldin,H;Lavie,G
培养人外周血单核细胞，并将其暴露于具有不同程度的促肿瘤活性的植物二萜、吲哚生物碱和聚乙酸酯。检查了上述遭遇对单核细胞功能的影响，如细胞产生的 H2O2 和狗红细胞的裂解以及各种测试剂对 3 H-PDBu 与单核细胞结合的抑制所表达的。激活单核细胞功能和抑制 3 H-PDBu 结合最有效的试剂是 12-0-十四烷酰佛波醇 13-乙酸酯 (TPA)、佛波醇 12、13 二丁酸酯、teleocidin 和海兔毒素，已知它们是强肿瘤促进剂。弱肿瘤促进剂佛波醇 12-视黄酸酯 13-乙酸酯、mezerein 和去溴海螺毒素也对单核细胞功能产生强烈刺激。非促肿瘤佛波醇二萜，如佛波醇 12、13-二乙酸酯、佛波醇 12-肉豆蔻酸酯、佛波醇 13-乙酸酯和 4-α TPA 在单核细胞刺激和抑制 3 H-PDBu 结合方面的效果比 TPA 低 1,000 倍。这些结果表明，刺激人单核细胞 H2O2 产生和相关的细胞毒性可能会有效地区分促肿瘤试剂和非促肿瘤试剂。
Human peripheral blood monocytes were cultured and exposed to plant diterpens, indole alkaloids and polyacetates with various degrees of tumor‐promoting activity. The effect of the above‐mentioned encounter on monocyte function was examined, as expressed by H2O2production and lysis of dog erythrocytes by the cells, and the inhibition of3H‐PDBu binding to the monocytes by the various test agents. The most effective reagents in both activation of monocyte function and inhibition of3H‐PDBu binding were 12‐0‐tetradecanoyl‐phorbol 13‐acetate (TPA), phorbol 12, 13 dibutyrate, teleocidin, and aplysiatoxin which are known to be strong tumor promoters. Strong stimulation of monocyte function was also exerted by the weak tumor promoters, phorbol 12‐retinoate 13‐acetate, mezerein and debromoaplysiatoxin. Non‐tumor‐promoting phorbol diterpens such as phorbol 12, 13‐diacetate, phorbol 12‐myristate, phorbol 13‐acetate and 4‐alpha TPA were 1,000 times less effective than TPA in monocyte stimulation and inhibition of3H‐PDBu binding. These results indicate that stimulation of human monocyte H2O2production and related cytotoxicity might discriminate effectively between tumor‐promoting and non‐tumor‐promoting reagents.
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