Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy.
Maternal, placental, and fetal distribution of titanium after repeated titanium dioxide nanoparticle inhalation through pregnancy.
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DOI：
10.1016/j.placenta.2022.03.008
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发表时间：
2022-04
期刊：
影响因子：
3.8
通讯作者：
Stapleton, P. A.
中科院分区：
文献类型：
--
作者：
D'Errico, J. N.;Doherty, C.;George, J. J. Reyes;Buckley, B.;Stapleton, P. A.
流行病学研究将环境工程纳米材料或超细颗粒物（PM0.1）（统称为纳米颗粒（NP））与不良妊娠结局（包括流产，早产和胎儿生长受限）相关联。来自非妊娠模型的证据表明，NP可以穿过肺气-血屏障并全身循环。因此，妊娠期间吸入NP导致胎儿胎盘暴露引起了关注。本研究的目的是评估吸入的二氧化钛纳米颗粒（nano-TiO 2）从母体肺到母体和胎儿全身组织的分布。在妊娠第4天（GD）至第19天，对妊娠Sprague道利大鼠进行全身暴露于过滤空气或纳米TiO 2气溶胶（9.96 ± 0.06 mg/m3）。在GD 20时，采集母体、胎盘和胎仔组织，然后消化用于ICP-MS分析，以测量钛（Ti）浓度。TEM用于观察胎盘合胞体的颗粒内化。结果表明，肺外分布的钛在怀孕期间的各种母体器官。我们的研究发现，Ti积聚在子宫角所有部分的胎盘的蜕膜/交界区和迷路区。此外，纳米粒子沉积在胎盘中，通过TEM鉴定，发现细胞内的核，内质网，和囊泡细胞器。本研究确定了妊娠模型中纳米TiO 2雾化吸入后Ti的全身分布和胎盘蓄积。这些发现引起了人们对孕妇空气质量差以及可能导致不良妊娠结局的担忧。
Epidemiological studies have associated ambient engineered nanomaterials or ultrafine particulate matter (PM0.1), collectively referred to as nanoparticles (NPs), with adverse pregnancy outcomes including miscarriage, preterm labor, and fetal growth restriction. Evidence from non-pregnant models demonstrate that NPs can cross the lung air-blood barrier and circulate systemically. Therefore, inhalation of NPs during pregnancy leading to fetoplacental exposure has garnered attention. The purpose of this study was to evaluate the distribution of inhaled titanium dioxide nanoparticles (nano-TiO2) from the maternal lung to maternal and fetal systemic tissues. Pregnant Sprague Dawley rats were administered whole-body exposure to filtered air or of nano-TiO2 aerosols (9.96 ± 0.06 mg/m3) between gestational day (GD) 4 and 19. On GD 20 maternal, placental, and fetal tissues were harvested then digested for ICP-MS analysis to measure concentrations of titanium (Ti). TEM was used to visualize particle internalization by the placental syncytium. The results demonstrate the extrapulmonary distribution of Ti to various maternal organs during pregnancy. Our study found Ti accumulation in the decidua/junctional and labyrinth zones of placentas embedded in all sections of uterine horns. Further, NPs deposited in the placenta, identified by TEM, were found intracellularly within nuclear, endoplasmic reticulum, and vesicle organelles. This study identified the systemic distribution and placental accumulation of Ti after nano-TiO2 aerosol inhalation in a pregnancy model. These findings arouse concerns for poor air quality for pregnant women and possible contributions to adverse pregnancy outcomes.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
10
作者：
Fournier SB;D'Errico JN;Adler DS;Kollontzi S;Goedken MJ;Fabris L;Yurkow EJ;Stapleton PA
通讯作者：
Stapleton PA
影响因子：
10
作者：
Lee, Jinsoo;Jeong, Ji-Seong;Yu, Wook-Joon
通讯作者：
Yu, Wook-Joon
影响因子：
2.6
作者：
Nakai, A.;Sekiya, I.;Araki, T.
通讯作者：
Araki, T.
影响因子：
1.2
作者：
D'Errico, Jeanine N.;Fournier, Sara B.;Stapleton, Phoebe A.
通讯作者：
Stapleton, Phoebe A.